MYCL1

From Wikipedia, the free encyclopedia
V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
Identifiers
SymbolsMYCL1; LMYC; MYCL; bHLHe38
External IDsOMIM: 164850 MGI: 96799 HomoloGene: 3921 GeneCards: MYCL1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez461016918
EnsemblENSG00000116990ENSMUSG00000028654
UniProtP12524P10166
RefSeq (mRNA)NM_001033081NM_008506
RefSeq (protein)NP_001028253NP_032532
Location (UCSC)Chr 1:
40.36 – 40.37 Mb
Chr 4:
123 – 123 Mb
PubMed search

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[1][2] MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[3]

Interactions

MYCL1 has been shown to interact with MAX.[4][5]

References

  1. Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772. 
  2. "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)". 
  3. Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. 
  4. Blackwood, E M; Eisenman R N (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science (UNITED STATES) 251 (4998): 1211–1217. doi:10.1126/science.2006410. ISSN 0036-8075. PMID 2006410. 
  5. FitzGerald, M J; Arsura M, Bellas R E, Yang W, Wu M, Chin L, Mann K K, DePinho R A, Sonenshein G E (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene (ENGLAND) 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. ISSN 0950-9232. PMID 10229200. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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