MXI1
From Wikipedia, the free encyclopedia
| MAX interactor 1, dimerization protein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MXI1; MAD2; MXD2; MXI; bHLHc11 | ||||||||||||
| External IDs | OMIM: 600020 MGI: 97245 HomoloGene: 4351 GeneCards: MXI1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4601 | 17859 | |||||||||||
| Ensembl | ENSG00000119950 | ENSMUSG00000025025 | |||||||||||
| UniProt | P50539 | P50540 | |||||||||||
| RefSeq (mRNA) | NM_001008541 | NM_001008542 | |||||||||||
| RefSeq (protein) | NP_001008541 | NP_001008542 | |||||||||||
| Location (UCSC) | Chr 10: 111.97 – 112.05 Mb | Chr 19: 53.31 – 53.38 Mb | |||||||||||
| PubMed search | |||||||||||||
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.[1][2]
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.[2]
Interactions
MXI1 has been shown to interact with SMC3[3] and MAX.[3][4][5][6][7]
References
- ↑ Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25". Genomics 21 (3): 669–72. doi:10.1006/geno.1994.1336. PMID 7959753.
- ↑ 2.0 2.1 "Entrez Gene: MXI1 MAX interactor 1".
- ↑ 3.0 3.1 Gupta, K; Anand G, Yin X, Grove L, Prochownik E V (Mar 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene (ENGLAND) 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. ISSN 0950-9232. PMID 9528857.
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Billin, A N; Eilers A L, Queva C, Ayer D E (Dec 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. (United States) 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. ISSN 0021-9258. PMID 10593926.
- ↑ Meroni, G; Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter D H, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. (ENGLAND) 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. ISSN 0261-4189. PMC 1169897. PMID 9184233.
- ↑ FitzGerald, M J; Arsura M, Bellas R E, Yang W, Wu M, Chin L, Mann K K, DePinho R A, Sonenshein G E (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene (ENGLAND) 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. ISSN 0950-9232. PMID 10229200.
Further reading
- Zervos AS, Gyuris J, Brent R (1993). "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites". Cell 72 (2): 223–32. doi:10.1016/0092-8674(93)90662-A. PMID 8425219.
- Zervos AS, Gyuris J, Brent R (1994). "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites" (PDF). Cell 79 (2): following 388. PMID 7954804.
- Schreiber-Agus N, Meng Y, Hoang T et al. (1998). "Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth". Nature 393 (6684): 483–7. doi:10.1038/31008. PMID 9624006.
- Eagle LR, Yin X, Brothman AR et al. (1995). "Mutation of the MXI1 gene in prostate cancer". Nat. Genet. 9 (3): 249–55. doi:10.1038/ng0395-249. PMID 7773287.
- Albarosa R, DiDonato S, Finocchiaro G (1995). "Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas". Hum. Genet. 95 (6): 709–11. doi:10.1007/BF00209493. PMID 7789959.
- Schreiber-Agus N, Chin L, Chen K et al. (1995). "An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3". Cell 80 (5): 777–86. doi:10.1016/0092-8674(95)90356-9. PMID 7889571.
- Edelhoff S, Ayer DE, Zervos AS et al. (1994). "Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19". Oncogene 9 (2): 665–8. PMID 8290278.
- Wechsler DS, Shelly CA, Dang CV (1997). "Genomic organization of human MXI1, a putative tumor suppressor gene". Genomics 32 (3): 466–70. doi:10.1006/geno.1996.0144. PMID 8838813.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Shimizu E, Shirasawa H, Kodama K et al. (1997). "Expression, regulation and polymorphism of the mxi1 genes". Gene 176 (1–2): 45–8. doi:10.1016/0378-1119(96)00206-5. PMID 8918230.
- Gupta K, Anand G, Yin X et al. (1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. PMID 9528857.
- Prochownik EV, Eagle Grove L, Deubler D et al. (1999). "Commonly occurring loss and mutation of the MXI1 gene in prostate cancer". Genes Chromosomes Cancer 22 (4): 295–304. doi:10.1002/(SICI)1098-2264(199808)22:4<295::AID-GCC5>3.0.CO;2-Q. PMID 9669667.
- Li XJ, Wang DY, Zhu Y et al. (1999). "Mxi1 mutations in human neurofibrosarcomas". Jpn. J. Cancer Res. 90 (7): 740–6. PMID 10470286.
- Benson LQ, Coon MR, Krueger LM et al. (1999). "Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2". J. Biol. Chem. 274 (40): 28794–802. doi:10.1074/jbc.274.40.28794. PMID 10497252.
- Taj MM, Tawil RJ, Engstrom LD et al. (2001). "Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells". Prostate 47 (3): 194–204. doi:10.1002/pros.1063. PMID 11351349.
- Yin X, Landay MF, Han W et al. (2001). "Dynamic in vivo interactions among Myc network members". Oncogene 20 (34): 4650–64. doi:10.1038/sj.onc.1204606. PMID 11498788.
- Manni I, Tunici P, Cirenei N et al. (2002). "Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression". Br. J. Cancer 86 (3): 477–84. doi:10.1038/sj.bjc.6600065. PMC 2375210. PMID 11875718.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ariyanayagam-Baksh SM, Baksh FK, Swalsky PA, Finkelstein SD (2004). "Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma". Mod. Pathol. 16 (10): 992–5. doi:10.1097/01.MP.0000087421.44975.1C. PMID 14559981.
External links
- MXI1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook Mxi1
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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