MUC5AC
From Wikipedia, the free encyclopedia
| Mucin 5AC, oligomeric mucus/gel-forming | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MUC5AC; MUC5; TBM; leB | ||||||||||||
| External IDs | OMIM: 158373 HomoloGene: 88249 GeneCards: MUC5AC Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4586 | n/a | |||||||||||
| Ensembl | ENSG00000215182 | n/a | |||||||||||
| UniProt | P98088 | n/a | |||||||||||
| RefSeq (mRNA) | NM_017511 | n/a | |||||||||||
| RefSeq (protein) | XP_003119529 | n/a | |||||||||||
| Location (UCSC) | Chr 11: 1.15 – 1.22 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene.[1][2][3]
Clinical relevance
This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD).[4]
References
- ↑ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J 305 (Pt 1): 211–9. PMC 1136451. PMID 7826332.
- ↑ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
- ↑ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
- ↑ Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med Genomics 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416. PMID 22676183.
Further reading
- Meezaman D, Charles P, Daskal E, et al. (1994). "Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5)". J. Biol. Chem. 269 (17): 12932–9. PMID 7513696.
- Lesuffleur T, Roche F, Hill AS, et al. (1995). "Characterization of a mucin cDNA clone isolated from HT-29 mucus-secreting cells. The 3' end of MUC5AC?". J. Biol. Chem. 270 (23): 13665–73. doi:10.1074/jbc.270.23.13665. PMID 7775418.
- Klomp LW, Van Rens L, Strous GJ (1997). "Cloning and analysis of human gastric mucin cDNA reveals two types of conserved cysteine-rich domains". Biochem. J. 308 (Pt 3): 831–8. PMC 1136799. PMID 8948439.
- Li D, Gallup M, Fan N, et al. (1998). "Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts". J. Biol. Chem. 273 (12): 6812–20. doi:10.1074/jbc.273.12.6812. PMID 9506983.
- Buisine MP, Desseyn JL, Porchet N, et al. (1998). "Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family". Biochem. J. 332 (Pt 3): 729–38. PMC 1219534. PMID 9620876.
- Tomasetto C, Masson R, Linares JL, et al. (2000). "pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins". Gastroenterology 118 (1): 70–80. doi:10.1016/S0016-5085(00)70415-X. PMID 10611155.
- Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
- Silverman HS, Parry S, Sutton-Smith M, et al. (2001). "In vivo glycosylation of mucin tandem repeats". Glycobiology 11 (6): 459–71. doi:10.1093/glycob/11.6.459. PMID 11445551.
- Escande F, Aubert JP, Porchet N, Buisine MP (2001). "Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region". Biochem. J. 358 (Pt 3): 763–72. doi:10.1042/0264-6021:3580763. PMC 1222110. PMID 11535137.
- Fischer BM, Voynow JA (2002). "Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species". Am. J. Respir. Cell Mol. Biol. 26 (4): 447–52. PMID 11919081.
- Nordman H, Davies JR, Lindell G, et al. (2002). "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution". Biochem. J. 364 (Pt 1): 191–200. PMC 1222561. PMID 11988092.
- Nollet S, Forgue-Lafitte ME, Kirkham P, Bara J (2002). "Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors". Int. J. Cancer 99 (3): 336–43. doi:10.1002/ijc.10335. PMID 11992401.
- Koo JS, Kim YD, Jetten AM, et al. (2002). "Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist". Exp. Lung Res. 28 (4): 315–32. doi:10.1080/01902140252964393. PMID 12042033.
- Guo JM, Zhang Y, Cheng L, et al. (2002). "Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12". FEBS Lett. 524 (1–3): 211–8. doi:10.1016/S0014-5793(02)03007-7. PMID 12135769.
- Kim GE, Bae HI, Park HU, et al. (2002). "Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas". Gastroenterology 123 (4): 1052–60. doi:10.1053/gast.2002.36018. PMID 12360467.
- Kim YD, Kwon EJ, Park DW, et al. (2002). "Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells". Mol. Pharmacol. 62 (5): 1112–8. doi:10.1124/mol.62.5.1112. PMID 12391274.
- Cheng L, Tachibana K, Zhang Y, et al. (2002). "Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10". FEBS Lett. 531 (2): 115–21. doi:10.1016/S0014-5793(02)03399-9. PMID 12417297.
- Baldus SE, Mönig SP, Arkenau V, et al. (2003). "Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma". Ann. Surg. Oncol. 9 (9): 887–93. doi:10.1007/BF02557526. PMID 12417511.
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