MT3

From Wikipedia, the free encyclopedia

Metallothionein 3

PDB rendering based on 2f5h.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2F5H, 2FJ4, 2FJ5

Identifiers

MT3; GIF; GIFB; GRIF; ZnMT3

External IDs

OMIM: 139255 MGI: 97173 HomoloGene: 4346 ChEMBL: 1250357 GeneCards: MT3 Gene

Gene Ontology
Molecular function	• copper ion binding • protein binding • drug binding • zinc ion binding • antioxidant activity • protein kinase activator activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • cadmium ion binding
Cellular component	• intracellular • cytoplasm • synaptic vesicle • inclusion body • perinuclear region of cytoplasm
Biological process	• protein import into nucleus, translocation • response to hypoxia • positive regulation of protein phosphorylation • energy reserve metabolic process • cholesterol catabolic process • zinc ion transport • cellular metal ion homeostasis • cellular zinc ion homeostasis • cell proliferation • negative regulation of autophagy • positive regulation of gene expression • positive regulation of necrotic cell death • positive regulation of cell death • astrocyte development • histone modification • removal of superoxide radicals • negative regulation of cell growth • negative regulation of axon extension • positive regulation of vascular endothelial growth factor receptor signaling pathway • regulation of response to food • activation of protein kinase B activity • leptin-mediated signaling pathway • cellular response to oxidative stress • cellular response to drug • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress • negative regulation of apoptotic process • positive regulation of catalytic activity • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • protein kinase B signaling cascade • negative regulation of neuron apoptotic process • cellular lipid catabolic process • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • protein stabilization • negative regulation of oxidoreductase activity • zinc ion homeostasis • cadmium ion homeostasis • regulation of protein glycosylation • negative regulation of necrotic cell death • ERK1 and ERK2 cascade • positive regulation of ERK1 and ERK2 cascade • cellular response to cadmium ion • cellular response to hypoxia • cellular response to nitric oxide • positive regulation of lysosomal membrane permeability • negative regulation of cysteine-type endopeptidase activity • positive regulation of oxygen metabolic process • negative regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000087250

ENSMUSG00000031760

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
56.62 – 56.63 Mb

Chr 8:
94.15 – 94.15 Mb

PubMed search

Metallothionein-3 is a protein that in humans is encoded by the MT3 gene.^[1]^[2]

References

↑ Palmiter RD, Findley SD, Whitmore TE, Durnam DM (Aug 1992). "MT-III, a brain-specific member of the metallothionein gene family". Proc Natl Acad Sci U S A 89 (14): 6333–7. doi:10.1073/pnas.89.14.6333. PMC 49495. PMID 1631128.
↑ "Entrez Gene: MT3 metallothionein 3".

Further reading

Aschner M (1996). "The functional significance of brain metallothioneins.". FASEB J. 10 (10): 1129–36. PMID 8751715.
Tsuji S, Kobayashi H, Uchida Y, et al. (1993). "Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.". EMBO J. 11 (13): 4843–50. PMC 556960. PMID 1464312.
Uchida Y, Takio K, Titani K, et al. (1991). "The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein.". Neuron 7 (2): 337–47. doi:10.1016/0896-6273(91)90272-2. PMID 1873033.
Hewitt JE, Gordon MM, Taggart RT, et al. (1991). "Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11.". Genomics 10 (2): 432–40. doi:10.1016/0888-7543(91)90329-D. PMID 2071148.
Amoureux MC, Wurch T, Pauwels PJ (1995). "Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes.". Biochem. Biophys. Res. Commun. 214 (2): 639–45. doi:10.1006/bbrc.1995.2334. PMID 7677777.
Naruse S, Igarashi S, Furuya T, et al. (1994). "Structures of the human and mouse growth inhibitory factor-encoding genes.". Gene 144 (2): 283–7. doi:10.1016/0378-1119(94)90391-3. PMID 8039715.
Moffatt P, Séguin C (1998). "Expression of the gene encoding metallothionein-3 in organs of the reproductive system.". DNA Cell Biol. 17 (6): 501–10. doi:10.1089/dna.1998.17.501. PMID 9655243.
Garrett SH, Sens MA, Shukla D, et al. (1999). "Metallothionein isoform 3 expression in the human prostate and cancer-derived cell lines.". Prostate 41 (3): 196–202. doi:10.1002/(SICI)1097-0045(19991101)41:3<196::AID-PROS7>3.0.CO;2-U. PMID 10517878.
Ye B, Maret W, Vallee BL (2001). "Zinc metallothionein imported into liver mitochondria modulates respiration.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2317–22. doi:10.1073/pnas.041619198. PMC 30136. PMID 11226237.
Kim D, Garrett SH, Sens MA, et al. (2002). "Metallothionein isoform 3 and proximal tubule vectorial active transport.". Kidney Int. 61 (2): 464–72. doi:10.1046/j.1523-1755.2002.00153.x. PMID 11849386.
Palumaa P, Eriste E, Njunkova O, et al. (2002). "Brain-specific metallothionein-3 has higher metal-binding capacity than ubiquitous metallothioneins and binds metals noncooperatively.". Biochemistry 41 (19): 6158–63. doi:10.1021/bi025664v. PMID 11994011.
Uchida Y, Gomi F, Masumizu T, Miura Y (2002). "Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging.". J. Biol. Chem. 277 (35): 32353–9. doi:10.1074/jbc.M111263200. PMID 12058024.
You HJ, Lee KJ, Jeong HG (2002). "Overexpression of human metallothionein-III prevents hydrogen peroxide-induced oxidative stress in human fibroblasts.". FEBS Lett. 521 (1–3): 175–9. doi:10.1016/S0014-5793(02)02870-3. PMID 12067712.
Roschitzki B, Vasák M (2002). "A distinct Cu(4)-thiolate cluster of human metallothionein-3 is located in the N-terminal domain". J. Biol. Inorg. Chem. 7 (6): 611–6. doi:10.1007/s00775-002-0339-1. PMID 12072966.
Dutta R, Sens DA, Somji S, et al. (2002). "Metallothionein isoform 3 expression inhibits cell growth and increases drug resistance of PC-3 prostate cancer cells". Prostate 52 (2): 89–97. doi:10.1002/pros.10097. PMID 12111700.
Tate DJ, Miceli MV, Newsome DA (2002). "Expression of metallothionein isoforms in human chorioretinal complex". Curr. Eye Res. 24 (1): 12–25. doi:10.1076/ceyr.24.1.12.5426. PMID 12187490.
You HJ, Oh DH, Choi CY, et al. (2002). "Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species". Biochim. Biophys. Acta 1573 (1): 33–8. PMID 12383939.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

PDB gallery

2f5h: Solution structure of the alpha-domain of human Metallothionein-3

2fj4: SOLUTION STRUCTURE OF a-domain of HUMAN Metallothionein-3 (MT-3)

2fj5: SOLUTION STRUCTURE OF sole a-domain of HUMAN Metallothionein-3 (MT-3)

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