MMS19

From Wikipedia, the free encyclopedia

MMS19 nucleotide excision repair homolog (S. cerevisiae)

Identifiers

MMS19; MET18; MMS19L; hMMS19

External IDs

OMIM: 614777 MGI: 1919449 HomoloGene: 41480 GeneCards: MMS19 Gene

Gene Ontology
Molecular function	• transcription coactivator activity • protein binding • receptor signaling complex scaffold activity • estrogen receptor binding • protein binding, bridging
Cellular component	• nucleus • holo TFIIH complex • cytoplasm • spindle • MMXD complex • CIA complex
Biological process	• phosphorelay signal transduction system • DNA metabolic process • DNA repair • nucleotide-excision repair • transcription, DNA-dependent • response to DNA damage stimulus • chromosome segregation • response to hormone stimulus • iron-sulfur cluster assembly • small molecule metabolic process • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000155229

ENSMUSG00000025159

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
99.22 – 99.26 Mb

Chr 19:
41.94 – 41.98 Mb

PubMed search

MMS19 nucleotide excision repair protein homolog is a protein that in humans is encoded by the MMS19 gene.^[1]^[2]

References

↑ Seroz T, Winkler GS, Auriol J, Verhage RA, Vermeulen W, Smit B, Brouwer J, Eker AP, Weeda G, Egly JM, Hoeijmakers JH (Nov 2000). "Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases". Nucleic Acids Res 28 (22): 4506–13. doi:10.1093/nar/28.22.4506. PMC 113875. PMID 11071939.
↑ "Entrez Gene: MMS19L MMS19-like (MET18 homolog, S. cerevisiae)".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wu X, Li H, Chen JD (2001). "The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor". J. Biol. Chem. 276 (26): 23962–8. doi:10.1074/jbc.M101041200. PMID 11279242.
Queimado L, Rao M, Schultz RA, et al. (2002). "Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant". Nucleic Acids Res. 29 (9): 1884–91. doi:10.1093/nar/29.9.1884. PMC 37259. PMID 11328871.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hatfield MD, Reis AM, Obeso D, et al. (2006). "Identification of MMS19 domains with distinct functions in NER and transcription". DNA Repair (Amst.) 5 (8): 914–24. doi:10.1016/j.dnarep.2006.05.007. PMID 16797255.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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