MLX (gene)
From Wikipedia, the free encyclopedia
Max-like protein X is a protein that in humans is encoded by the MLX gene.[1][2]
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]
Interactions
MLX (gene) has been shown to interact with MNT,[3][4] MXD1[3][4] and MLXIPL.[3]
References
- ↑ Bjerknes M, Cheng H (January 1997). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301.
- ↑ 2.0 2.1 "Entrez Gene: MLX MAX-like protein X".
- ↑ 3.0 3.1 3.2 Cairo, S; Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–27. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181.
- ↑ 4.0 4.1 Meroni, G; Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583.
Further reading
- Rommens JM, Durocher F, McArthur J et al. (1996). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Billin AN, Eilers AL, Queva C, Ayer DE (2000). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.
- Meroni G, Cairo S, Merla G et al. (2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.
- Billin AN, Eilers AL, Coulter KL et al. (2000). "MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network". Mol. Cell. Biol. 20 (23): 8845–54. doi:10.1128/MCB.20.23.8845-8854.2000. PMC 86535. PMID 11073985.
- Cairo S, Merla G, Urbinati F et al. (2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
- Eilers AL, Sundwall E, Lin M et al. (2003). "A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex". Mol. Cell. Biol. 22 (24): 8514–26. doi:10.1128/MCB.22.24.8514-8526.2002. PMC 139889. PMID 12446771.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Merla G, Howald C, Antonarakis SE, Reymond A (2005). "The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3". Hum. Mol. Genet. 13 (14): 1505–14. doi:10.1093/hmg/ddh163. PMID 15163635.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ma L, Tsatsos NG, Towle HC (2005). "Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes". J. Biol. Chem. 280 (12): 12019–27. doi:10.1074/jbc.M413063200. PMID 15664996.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Sans CL, Satterwhite DJ, Stoltzman CA et al. (2006). "MondoA-Mlx Heterodimers Are Candidate Sensors of Cellular Energy Status: Mitochondrial Localization and Direct Regulation of Glycolysis". Mol. Cell. Biol. 26 (13): 4863–71. doi:10.1128/MCB.00657-05. PMC 1489152. PMID 16782875.
External links
- MLX protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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