MKL1

From Wikipedia, the free encyclopedia

Megakaryoblastic leukemia (translocation) 1

Rendering based on PDB 2KVU.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2KVU, 2KW9

Identifiers

Symbols

MKL1; BSAC; MAL; MRTF-A

External IDs

OMIM: 606078 MGI: 2384495 HomoloGene: 32487 GeneCards: MKL1 Gene

Gene Ontology
Molecular function	• transcription regulatory region sequence-specific DNA binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • actin monomer binding • protein binding • leucine zipper domain binding
Cellular component	• nucleus • nucleolus • cytoplasm
Biological process	• transcription, DNA-dependent • negative regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter • smooth muscle cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
40.81 – 41.03 Mb

Chr 15:
81.01 – 81.19 Mb

PubMed search

MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.^[1]^[2]^[3]^[4]

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.^[4]

References

↑ Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet 28 (3): 220–1. doi:10.1038/90054. PMID 11431691.
↑ Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano H (Aug 2002). "Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death". J Biol Chem 277 (32): 28853–60. doi:10.1074/jbc.M203190200. PMID 12019265.
↑ Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS (Apr 2004). "Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells". J Biol Chem 279 (17): 17578–86. doi:10.1074/jbc.M400961200. PMID 14970199.
↑ 4.0 4.1 "Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1".

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Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Selvaraj A, Prywes R (2005). "Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent.". BMC Mol. Biol. 5: 13. doi:10.1186/1471-2199-5-13. PMC 516031. PMID 15329155.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hsiao HH, Yang MY, Liu YC, et al. (2005). "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.". Am. J. Hematol. 79 (1): 43–5. doi:10.1002/ajh.20298. PMID 15849773.
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MKL1

References

Further reading