MID2
From Wikipedia, the free encyclopedia
| Midline 2 | |||||||||||||
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 PDB rendering based on 2dja. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MID2; FXY2; RNF60; TRIM1 | ||||||||||||
| External IDs | OMIM: 300204 MGI: 1344333 HomoloGene: 8028 GeneCards: MID2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11043 | 23947 | |||||||||||
| Ensembl | ENSG00000080561 | ENSMUSG00000000266 | |||||||||||
| UniProt | Q9UJV3 | Q9QUS6 | |||||||||||
| RefSeq (mRNA) | NM_012216 | NM_011845 | |||||||||||
| RefSeq (protein) | NP_036348 | NP_035975 | |||||||||||
| Location (UCSC) | Chr X: 107.07 – 107.17 Mb | Chr X: 140.66 – 140.77 Mb | |||||||||||
| PubMed search | |||||||||||||
Midline-2 is a protein that in humans is encoded by the MID2 gene.[1][2]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[2]
Interactions
MID2 has been shown to interact with MID1.[3][4]
References
- ↑ Buchner G, Montini E, Andolfi G, Quaderi N, Cainarca S, Messali S, Bassi MT, Ballabio A, Meroni G, Franco B (Sep 1999). "MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development". Hum Mol Genet 8 (8): 1397–407. doi:10.1093/hmg/8.8.1397. PMID 10400986.
- ↑ 2.0 2.1 "Entrez Gene: MID2 midline 2".
- ↑ Reymond, A; Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci P G, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. (England) 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. ISSN 0261-4189. PMC 125245. PMID 11331580.
- ↑ Short, Kieran M; Hopwood Blair, Yi Zou, Cox Timothy C (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders". BMC Cell Biol. (England) 3: 1. doi:10.1186/1471-2121-3-1. PMC 64779. PMID 11806752.
Further reading
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Jehee FS, Rosenberg C, Krepischi-Santos AC, et al. (2006). "An Xq22.3 duplication detected by comparative genomic hybridization microarray (Array-CGH) defines a new locus (FGS5) for FG syndrome.". Am. J. Med. Genet. A 139 (3): 221–6. doi:10.1002/ajmg.a.30991. PMID 16283679.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yap MW, Nisole S, Lynch C, Stoye JP (2004). "Trim5alpha protein restricts both HIV-1 and murine leukemia virus.". Proc. Natl. Acad. Sci. U.S.A. 101 (29): 10786–91. doi:10.1073/pnas.0402876101. PMC 490012. PMID 15249690.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Short KM, Hopwood B, Yi Z, Cox TC (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.". BMC Cell Biol. 3: 1. doi:10.1186/1471-2121-3-1. PMC 64779. PMID 11806752.
- Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
- Perry J, Short KM, Romer JT, et al. (2000). "FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes an FNIII domain-containing protein that associates with microtubules.". Genomics 62 (3): 385–94. doi:10.1006/geno.1999.6043. PMID 10644436.
- Cainarca S, Messali S, Ballabio A, Meroni G (1999). "Functional characterization of the Opitz syndrome gene product (midin): evidence for homodimerization and association with microtubules throughout the cell cycle.". Hum. Mol. Genet. 8 (8): 1387–96. doi:10.1093/hmg/8.8.1387. PMID 10400985.
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