MED6
From Wikipedia, the free encyclopedia
| Mediator complex subunit 6 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MED6; NY-REN-28 | ||||||||||||
| External IDs | OMIM: 602984 MGI: 1917042 HomoloGene: 3990 GeneCards: MED6 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10001 | 69792 | |||||||||||
| Ensembl | ENSG00000133997 | ENSMUSG00000002679 | |||||||||||
| UniProt | O75586 | Q921D4 | |||||||||||
| RefSeq (mRNA) | NM_005466 | NM_027213 | |||||||||||
| RefSeq (protein) | NP_005457 | NP_081489 | |||||||||||
| Location (UCSC) | Chr 14: 71.05 – 71.07 Mb | Chr 12: 81.57 – 81.6 Mb | |||||||||||
| PubMed search | |||||||||||||
| Med6 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Med6 | ||||||||
| Pfam | PF04934 | ||||||||
| InterPro | IPR007018 | ||||||||
| |||||||||
Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.[1][2][3]
Interactions
MED6 has been shown to interact with Thyroid hormone receptor alpha,[4] Estrogen receptor alpha,[5] MED21[6] and Cyclin-dependent kinase 8.[7][8][4][5]
Protein family details
This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.[1]
References
- ↑ 1.0 1.1 Lee YC, Min S, Gim BS, Kim YJ (Aug 1997). "A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans". Mol Cell Biol 17 (8): 4622–32. PMC 232315. PMID 9234719.
- ↑ Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A 95 (15): 8538–8543. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
- ↑ "Entrez Gene: MED6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)".
- ↑ 4.0 4.1 Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (UNITED STATES) 3 (3): 361–370. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638.
- ↑ 5.0 5.1 Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–2647. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
- ↑ Sun, X; Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell (UNITED STATES) 2 (2): 213–222. doi:10.1016/S1097-2765(00)80131-8. ISSN 1097-2765. PMID 9734358.
- ↑ Yang, Fajun; DeBeaumont Rosalie, Zhou Sharleen, Näär Anders M (Feb 2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (8): 2339–2344. doi:10.1073/pnas.0308676100. ISSN 0027-8424. PMC 356952. PMID 14983011.
- ↑ Wang, G; Cantin G T, Stevens J L, Berk A J (Jul 2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. (United States) 21 (14): 4604–4613. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Sun X, Zhang Y, Cho H et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell 2 (2): 213–222. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
- Gu W, Malik S, Ito M et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
- Ito M, Yuan CX, Malik S et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell 3 (3): 361–370. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
- Rachez C, Lemon BD, Suldan Z et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature 398 (6730): 824–828. doi:10.1038/19783. PMID 10235266.
- Näär AM, Beaurang PA, Zhou S et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature 398 (6730): 828–832. doi:10.1038/19789. PMID 10235267.
- Scanlan MJ, Gordan JD, Williamson B et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Ge K, Guermah M, Yuan CX et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature 417 (6888): 563–567. doi:10.1038/417563a. PMID 12037571.
- Kato Y, Habas R, Katsuyama Y et al. (2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal signalling". Nature 418 (6898): 641–646. doi:10.1038/nature00969. PMID 12167862.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sato S, Tomomori-Sato C, Banks CA et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–15127. doi:10.1074/jbc.C300054200. PMID 12584197.
- Sato S, Tomomori-Sato C, Banks CA et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–49674. doi:10.1074/jbc.C300444200. PMID 14576168.
- Tomomori-Sato C, Sato S, Parmely TJ et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–5851. doi:10.1074/jbc.M312523200. PMID 14638676.
- Yang F, DeBeaumont R, Zhou S, Näär AM (2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–2344. doi:10.1073/pnas.0308676100. PMC 356952. PMID 14983011.
- Sato S, Tomomori-Sato C, Parmely TJ et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell 14 (5): 685–691. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Pavri R, Lewis B, Kim TK et al. (2005). "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator". Mol. Cell 18 (1): 83–96. doi:10.1016/j.molcel.2005.02.034. PMID 15808511.
External links
- MED6 human gene location in the UCSC Genome Browser.
- MED6 human gene details in the UCSC Genome Browser.
This article incorporates text from the public domain Pfam and InterPro IPR007018
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.