MED21
From Wikipedia, the free encyclopedia
| Mediator complex subunit 21 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MED21; SRB7; SURB7; hSrb7 | ||||||||||||
| External IDs | OMIM: 603800 MGI: 1347064 HomoloGene: 3148 GeneCards: MED21 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9412 | 108098 | |||||||||||
| Ensembl | ENSG00000152944 | ENSMUSG00000030291 | |||||||||||
| UniProt | Q13503 | Q9CQ39 | |||||||||||
| RefSeq (mRNA) | NM_001271811 | NM_025315 | |||||||||||
| RefSeq (protein) | NP_001258740 | NP_079591 | |||||||||||
| Location (UCSC) | Chr 12: 27.18 – 27.22 Mb | Chr 6: 146.64 – 146.65 Mb | |||||||||||
| PubMed search | |||||||||||||
Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.[1][2]
Interactions
MED21 has been shown to interact with Cyclin-dependent kinase 8,[3][4][5][6] BRCA1,[7] GTF2H4,[7] MED6,[8] POLR2A[3][4][7] and GTF2F1.[4][7]
References
- ↑ Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA (Apr 1996). "A mammalian SRB protein associated with an RNA polymerase II holoenzyme". Nature 380 (6569): 82–5. doi:10.1038/380082a0. PMID 8598913.
- ↑ "Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast)".
- ↑ 3.0 3.1 Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. (United States) 18 (9): 5355–63. ISSN 0270-7306. PMC 109120. PMID 9710619.
- ↑ 4.0 4.1 4.2 Suñé, C; Hayashi T, Liu Y, Lane W S, Young R A, Garcia-Blanco M A (Oct 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. (United States) 17 (10): 6029–39. ISSN 0270-7306. PMC 232452. PMID 9315662.
- ↑ Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (United States) 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638.
- ↑ Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.
- ↑ 7.0 7.1 7.2 7.3 Scully, R; Anderson S F, Chao D M, Wei W, Ye L, Young R A, Livingston D M, Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (United States) 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMC 20825. PMID 9159119.
- ↑ Sun, X; Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell (United States) 2 (2): 213–22. doi:10.1016/S1097-2765(00)80131-8. ISSN 1097-2765. PMID 9734358.
Further reading
- Zheng XM, Black D, Chambon P, Egly JM (1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3.". Nature 344 (6266): 556–9. doi:10.1038/344556a0. PMID 2320128.
- Maldonado E, Shiekhattar R, Sheldon M, et al. (1996). "A human RNA polymerase II complex associated with SRB and DNA-repair proteins.". Nature 381 (6577): 86–9. doi:10.1038/381086a0. PMID 8609996.
- Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817–23. PMC 232028. PMID 9121429.
- Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
- Pan G, Aso T, Greenblatt J (1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators.". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
- Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure.". Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619.
- Sun X, Zhang Y, Cho H, et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.". Mol. Cell 2 (2): 213–22. doi:10.1016/S1097-2765(00)80131-8. PMID 9734358.
- Garriga J, Peng J, Parreño M, et al. (1999). "Upregulation of cyclin T1/CDK9 complexes during T cell activation.". Oncogene 17 (24): 3093–102. doi:10.1038/sj.onc.1202548. PMID 9872325.
- Gu W, Malik S, Ito M, et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.". Mol. Cell 3 (1): 97–108. doi:10.1016/S1097-2765(00)80178-1. PMID 10024883.
- Ramanathan Y, Rajpara SM, Reza SM, et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.". J. Biol. Chem. 276 (14): 10913–20. doi:10.1074/jbc.M010975200. PMID 11278802.
- Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
- Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.". Nature 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
- Wallberg AE, Yamamura S, Malik S, et al. (2004). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.". Mol. Cell 12 (5): 1137–49. doi:10.1016/S1097-2765(03)00391-5. PMID 14636573.
- Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
- Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Nevado J, Tenbaum SP, Aranda A (2005). "hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.". Mol. Cell. Endocrinol. 222 (1-2): 41–51. doi:10.1016/j.mce.2004.05.003. PMID 15249124.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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