MARCH6

From Wikipedia, the free encyclopedia

Membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase

Identifiers

MARCH6; DOA10; MARCH-VI; RNF176; TEB4

External IDs

OMIM: 613297 MGI: 2442773 HomoloGene: 4301 GeneCards: MARCH6 Gene

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • zinc ion binding • enzyme binding • ubiquitin conjugating enzyme binding
Cellular component	• integral to endoplasmic reticulum membrane
Biological process	• protein K48-linked ubiquitination
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000145495

ENSMUSG00000039100

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
10.35 – 10.44 Mb

Chr 15:
31.46 – 31.53 Mb

PubMed search

E3 ubiquitin-protein ligase MARCH6 is an enzyme that in humans is encoded by the MARCH6 gene.^[1]^[2]

References

↑ Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
↑ "Entrez Gene: MARCH6 membrane-associated ring finger (C3HC4) 6".

Further reading

Kreft SG, Wang L, Hochstrasser M (2006). "Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI).". J. Biol. Chem. 281 (8): 4646–53. doi:10.1074/jbc.M512215200. PMID 16373356.
Hassink G, Kikkert M, van Voorden S, et al. (2005). "TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum.". Biochem. J. 388 (Pt 2): 647–55. doi:10.1042/BJ20041241. PMC 1138973. PMID 15673284.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Swanson R, Locher M, Hochstrasser M (2001). "A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation.". Genes Dev. 15 (20): 2660–74. doi:10.1101/gad.933301. PMC 312819. PMID 11641273.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

External links

MARCH6 human gene location in the UCSC Genome Browser.
MARCH6 human gene details in the UCSC Genome Browser.

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