Lynestrenol

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Lynestrenol
Systematic (IUPAC) name
(8R,9R,10R,13S,14S,17S)-17-ethynyl-13-methyl-
2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-
1H-cyclopenta[a]phenanthren-17-ol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Identifiers
CAS number 52-76-6 YesY
ATC code G03AC02 G03DC03;
G03AA03 G03AB02 G03FA07 G03FB02 (combinations with estrogens)
PubChem CID 5857
ChemSpider 5648 YesY
UNII N2Z8ALG4U5 YesY
KEGG D01580 YesY
Chemical data
Formula C20H28O 
Mol. mass 284.436 g/mol
 YesY (what is this?)  (verify)

Lynestrenol is a progestogen hormone. It is a synthetic orally-available progestagen associated with numerous effects of the natural progesterone hormone. Lynestrenol has a strong progestational effect on the uterine endometrium (transforming proliferative endometrium into secretory one), inhibits secretion of gonadotropin, suppresses maturation of follicles in the ovaries and ovulation, reduces menstrual bleeding. This synthetic gestagen is associated with minimal estrogenic, androgenic and anabolic effects. Lynestrenol is used in treatment of hormonal disorders and diseases caused by insufficient secretion of the natural progesterone, except in case of risky pregnancies and prevention of miscarriage, since it is not efficient enough in this indication.

Pharmacology

After oral administration lynestrenol is quickly resorbed and converted into pharmacologically active norethisterone, through which it demonstrates the main biological effects. The peak blood are reached within 2–4 hours after oral administration, 97% of the administered dose being bound to plasma proteins. Lynestrenol and its metabolites are predominantly excreted in the urine, less through feces, active metabolite norethisterone elimination halftime being 16-17 h.

See also

References


    Estrogens and progestogens (G03C-D, L02)
    Progestogens
    Agonist
    1st
    2nd
    3rd
    4th
    17-OH
    Other/
    ungrouped
    Antiprogestogens/
    SPRMs
    Estrogens
    Agonists
    Steroidal
    Nonsteroidal
    Antiestrogens/
    SERMs
    Aromatase inhibitors

    M: ♀ FRS

    anat/phys/devp

    noco/cong/npls, sysi/epon

    proc/asst, drug (G1/G2B/G3CD)


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