Lucey–Driscoll syndrome
From Wikipedia, the free encyclopedia
| Lucey–Driscoll syndrome | |
|---|---|
| Classification and external resources | |
| ICD-9 | 774.30 |
| OMIM | 237900 |
| DiseasesDB | 32677 |
Lucey–Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism.
It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.
Cause
The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast feeding-associated jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).
Genetics
Lucey–Driscoll syndrome has an autosomal recessive pattern of inheritance.
A defect in the UGT1A1-gene, also linked to Crigler–Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey–Driscoll syndrome.
External links
- Online 'Mendelian Inheritance in Man' (OMIM) 237900 - transient familial neonatal hyperbilirubinemia, breast feeding jaundice included
- Hyperbilirubinemia, Unconjugated at eMedicine
- Lucey Driscoll syndrome at NIH's Office of Rare Diseases
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