Litoxetine

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Litoxetine
Systematic (IUPAC) name
4-(naphthalen-2-ylmethoxy)piperidine
Clinical data
Legal status ?
Identifiers
CAS number 86811-09-8
ATC code None
PubChem CID 65650
ChemSpider 59087
UNII 9980ST005G YesY
ChEMBL CHEMBL471036
Chemical data
Formula C16H19NO 
Mol. mass 241.327 g/mol

Litoxetine (SL 81-0385) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s.[1] It acts as a serotonin reuptake inhibitor and 5-HT3 receptor antagonist. It has prominent antiemetic properties, and unlike the selective serotonin reuptake inhibitors (SSRIs), it was shown to have a negligible incidence of nausea and emesis.[2] Development of litoxetine for medicinal use was apparently halted in the late 1990s.

References

  1. ↑ Fairweather DB, Patat A, Rosenzweig P, Curson VH, Dunmore C, Dubruc C, Hindmarch I (August 1995). "The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers". British Journal of Clinical Pharmacology 40 (2): 119–25. PMC 1365170. PMID 8562293. 
  2. ↑ Angel I, Schoemaker H, Prouteau M, Garreau M, Langer SZ (March 1993). "Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties". European Journal of Pharmacology 232 (2-3): 139–45. doi:10.1016/0014-2999(93)90767-C. PMID 8385615. 


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