Lercanidipine
From Wikipedia, the free encyclopedia
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|---|---|
| Systematic (IUPAC) name | |
| 2[(3,3-diphenylpropyl)(methyl)amino]-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Legal status | ? |
| Identifiers | |
| CAS number | 100427-26-7 |
| ATC code | C08CA13 |
| PubChem | CID 65866 |
| DrugBank | DB00528 |
| ChemSpider | 59276  |
| UNII | V7XTJ4R0BH |
| KEGG | D08111 |
| ChEMBL | CHEMBL250270 |
| Chemical data | |
| Formula | C36H41N3O6 |
| Mol. mass | 611.727 g/mol |
| SMILES
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| (what is this?) (verify) | |
Lercanidipine is a calcium channel blocker of the dihydropyridine class,which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. It is sold under various commercial names including Zanidip. This lowers the blood pressure and allows the heart to work more efficiently.[1]
References
- ↑ Barrios, V; Escobar, C; Navarro, A; Barrios, L; Navarro-Cid, J; Calderón, A; Laura, Investigators (2006). "Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study". International journal of clinical practice 60 (11): 1364–70. doi:10.1111/j.1742-1241.2006.01176.x. PMC 1636683. PMID 17073834.
Further reading
- Lin T, Voon W, Yen H, Huang C, Su H, Lai W, Sheu S (2006). "Lercanidipine and losartan effects on blood pressure and fibrinolytic parameters". Kaohsiung J Med Sci 22 (4): 177–83. doi:10.1016/S1607-551X(09)70304-3. PMID 16679299.
- Martinez M, Lopes L, Coelho E, Nobre F, Rocha J, Gerlach R, Tanus-Santos J (2006). "Lercanidipine reduces matrix metalloproteinase-9 activity in patients with hypertension". J Cardiovasc Pharmacol 47 (1): 117–22. doi:10.1097/01.fjc.0000196241.96759.71. PMID 16424795.
- Agrawal R, Marx A, Haller H (2006). "Efficacy and safety of lercanidipine versus hydrochlorothiazide as add-on to enalapril in diabetic populations with uncontrolled hypertension". J Hypertens 24 (1): 185–92. doi:10.1097/01.hjh.0000198987.34588.11. PMID 16331117.
External links
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