LSD1

From Wikipedia, the free encyclopedia

Not to be confused with LSD or Lysergic acid diethylamide.

Lysine (K)-specific demethylase 1A

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 2Z3Y, 2Z5U, 3ABT, 3ABU, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1

Identifiers

Symbols

KDM1A; AOF2; BHC110; KDM1; LSD1

External IDs

OMIM: 609132 HomoloGene: 32240 GeneCards: KDM1A Gene

Gene Ontology
Molecular function	• RNA polymerase II transcription factor binding • p53 binding • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • oxidoreductase activity • enzyme binding • ligand-dependent nuclear receptor transcription coactivator activity • demethylase activity • histone demethylase activity • histone demethylase activity (H3-K4 specific) • histone demethylase activity (H3-K9 specific) • histone demethylase activity (H3-dimethyl-K4 specific) • MRF binding • transcription regulatory region DNA binding • flavin adenine dinucleotide binding • androgen receptor binding
Cellular component	• nuclear chromatin • nucleus • nucleoplasm • transcription factor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • in utero embryonic development • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • protein demethylation • blood coagulation • cell proliferation • regulation of primitive erythrocyte differentiation • pituitary gland development • granulocyte differentiation • negative regulation of protein binding • histone H3-K9 demethylation • histone H3-K4 demethylation • negative regulation of apoptotic process • negative regulation of DNA binding • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of erythrocyte differentiation • positive regulation of megakaryocyte differentiation • negative regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of hormone biosynthetic process • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of histone H3-K4 methylation • negative regulation of histone H3-K9 methylation • muscle cell development • positive regulation of neural precursor cell proliferation • positive regulation of stem cell proliferation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
23.35 – 23.41 Mb

Chr 4:
136.55 – 136.6 Mb

PubMed search

LSD1 is a gene which codes a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9 (H3K4 and H3K9).

Lysine (K)-specific demethylase 1A is a protein in humans that is encoded by the KDM1A gene. ^[1]

Function

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

LSD1 (lysine-specific demethylase 1), also known as KDM1, is the first of several protein lysine demethylases discovered. Through a FAD-dependent oxidative reaction, LSD1 speficially removes histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. It's now known LSD1 complex mediates a coordinated histone modification switch through enzymatic activities as well as histone modification readers in the complex.

References

↑ "Entrez Gene: Lysine (K)-specific demethylase 1A". Retrieved 2013-06-27T04:30:00.492071-08:00.

External links

lysine specific demethylase 1, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.

LSD1

Function

See also

References

External links