LRP6

Low density lipoprotein receptor-related protein 6
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3S2K, 3S8V, 3S8Z, 3S94, 3SOB, 3SOQ, 3SOV, 4A0P, 4DG6
Identifiers
Symbols	LRP6; ADCAD2
External IDs	OMIM: 603507 MGI: 1298218 HomoloGene: 1747 GeneCards: LRP6 Gene
Gene Ontology Molecular function • low-density lipoprotein receptor activity • receptor binding • frizzled binding • protein binding • Wnt-protein binding • kinase inhibitor activity • toxin transporter activity • apolipoprotein binding • protein homodimerization activity • Wnt-activated receptor activity • coreceptor activity involved in Wnt receptor signaling pathway Cellular component • early endosome • endoplasmic reticulum • plasma membrane • caveola • cell surface • integral to membrane • cytoplasmic vesicle • neuronal cell body • receptor complex • synapse Biological process • gastrulation with mouth forming second • neural tube closure • negative regulation of protein phosphorylation • heart looping • positive regulation of mesenchymal cell proliferation • pericardium morphogenesis • negative regulation of protein kinase activity • synaptic transmission • embryonic pattern specification • anterior/posterior pattern specification • neural crest formation • neural crest cell differentiation • Wnt receptor signaling pathway • cerebellum morphogenesis • thalamus development • cerebral cortex cell migration • forebrain radial glial cell differentiation • Wnt receptor signaling pathway involved in forebrain neuroblast division • formation of radial glial scaffolds • cerebral cortex development • regulation of ossification • embryonic limb morphogenesis • midbrain development • midbrain-hindbrain boundary development • negative regulation of smooth muscle cell apoptotic process • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • external genitalia morphogenesis • post-anal tail morphogenesis • cell migration involved in gastrulation • odontogenesis of dentin-containing tooth • embryonic digit morphogenesis • positive regulation of apoptotic process • Wnt receptor signaling pathway involved in dorsal/ventral axis specification • canonical Wnt receptor signaling pathway involved in neural crest cell differentiation • canonical Wnt receptor signaling pathway involved in regulation of cell proliferation • regulation of fat cell differentiation • negative regulation of fat cell differentiation • positive regulation of ossification • positive regulation of bone resorption • positive regulation of cell cycle • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • bone remodeling • embryonic camera-type eye morphogenesis • negative regulation of epithelial cell proliferation • positive regulation of sequence-specific DNA binding transcription factor activity • response to folic acid • palate development • convergent extension • embryonic retina morphogenesis in camera-type eye • canonical Wnt receptor signaling pathway • regulation of cell development • face morphogenesis • bone morphogenesis • branching involved in mammary gland duct morphogenesis • trachea cartilage morphogenesis • mammary placode formation • canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development • canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation • cellular response to cholesterol • dopaminergic neuron differentiation • negative regulation of protein serine/threonine kinase activity • primitive streak formation • receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport • Wnt receptor signaling pathway involved in somitogenesis • axis elongation involved in somitogenesis • positive regulation of canonical Wnt receptor signaling pathway • toxin transport • positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification • negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis • negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis • negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis • negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis • negative regulation of planar cell polarity pathway involved in pericardium morphogenesis • negative regulation of planar cell polarity pathway involved in neural tube closure Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4040	16974
Ensembl	ENSG00000070018	ENSMUSG00000030201
UniProt	O75581	O88572
RefSeq (mRNA)	NM_002336	NM_008514
RefSeq (protein)	NP_002327	NP_032540
Location (UCSC)	Chr 12: 12.27 – 12.42 Mb	Chr 6: 134.45 – 134.57 Mb
PubMed search
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Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene.^[1][2]

Interactions

LRP6 has been shown to interact with DKK1.^[3]

References

Further reading