LMO2
LIM domain only 2 (rhombotin-like 1), also known as LMO2, is a protein which in humans is encoded by the LMO2 gene.[1]
Function
LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis(9). The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of T-cell acute lymphoblastic leukemia-specific translocations occur.[2]
Interactions
LMO2 has been shown to interact with JARID1A,[3] GATA1,[4] GATA2,[4] TAL1[4][5][6][7] and MLLT4.[8]
References
- ↑ Boehm, T. (1991). "The Rhombotin Family of Cysteine-Rich LIM-Domain Oncogenes: Distinct Members are Involved in T-Cell Translocations to Human Chromosomes 11p15 and 11p13". Proceedings of the National Academy of Sciences 88 (10): 4367–71. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676.
- ↑ EntrezGene 4005
- ↑ Mao, Shifeng; Neale, Geoffrey AM; Goorha, Rakesh M (1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID 9129143.
- ↑ 4.0 4.1 4.2 Osada, H. (1995). "Association of Erythroid Transcription Factors: Complexes Involving the LIM Protein RBTN2 and the Zinc-Finger Protein GATA1". Proceedings of the National Academy of Sciences 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
- ↑ Wadman, I; Li, J; Bash, RO; Forster, A; Osada, H; Rabbitts, TH; Baer, R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal 13 (20): 4831–9. PMC 395422. PMID 7957052.
- ↑ Valge-Archer, V. E. (1994). "The LIM Protein RBTN2 and the Basic Helix-Loop-Helix Protein TAL1 are Present in a Complex in Erythroid Cells". Proceedings of the National Academy of Sciences 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
- ↑ Goardon, Nicolas; Lambert, Julie A; Rodriguez, Patrick; Nissaire, Philippe; Herblot, Sabine; Thibault, Pierre; Dumenil, Dominique; Strouboulis, John et al. (2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". The EMBO Journal 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
- ↑ Begaymuller, V; Ansieau, S; Leutz, A (2002). "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene". FEBS Letters 521 (1–3): 36–8. doi:10.1016/S0014-5793(02)02814-4. PMID 12067721.
9. ^ Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994 Jul 15;78(1):45-57. PMID 8033210
Further reading
- Royer-Pokora, B; Loos, U; Ludwig, WD (1991). "TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)". Oncogene 6 (10): 1887–93. PMID 1923511.
- Boehm, T. (1991). "The Rhombotin Family of Cysteine-Rich LIM-Domain Oncogenes: Distinct Members are Involved in T-Cell Translocations to Human Chromosomes 11p15 and 11p13". Proceedings of the National Academy of Sciences 88 (10): 4367–71. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676.
- Boehm, T; Spillantini, MG; Sofroniew, MV; Surani, MA; Rabbitts, TH (1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: Evidence for thymus expression". Oncogene 6 (5): 695–703. PMID 2052354.
- Dong, WF; Xu, Y; Hu, QL; Munroe, D; Minowada, J; Housman, DE; Minden, MD (1995). "Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1". Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 9 (11): 1812–7. PMID 7475267.
- Osada, H. (1995). "Association of Erythroid Transcription Factors: Complexes Involving the LIM Protein RBTN2 and the Zinc-Finger Protein GATA1". Proceedings of the National Academy of Sciences 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
- Sánchez-García, I; Axelson, H; Rabbitts, TH (1995). "Functional diversity of LIM proteins: Amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2". Oncogene 10 (7): 1301–6. PMID 7731680.
- Wadman, I; Li, J; Bash, RO; Forster, A; Osada, H; Rabbitts, TH; Baer, R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal 13 (20): 4831–9. PMC 395422. PMID 7957052.
- Valge-Archer, V. E. (1994). "The LIM Protein RBTN2 and the Basic Helix-Loop-Helix Protein TAL1 are Present in a Complex in Erythroid Cells". Proceedings of the National Academy of Sciences 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
- Wilkinson, D A; Neale, G A M; Mao, S; Naeve, C W; Goorha, R M (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: Discovery and potential role in T cell leukemia". Leukemia 11 (1): 86–96. doi:10.1038/sj.leu.2400516. PMID 9001422.
- Mao, Shifeng; Neale, Geoffrey AM; Goorha, Rakesh M (1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID 9129143.
- Osada, H; Grutz, GG; Axelson, H; Forster, A; Rabbitts, TH (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 11 Suppl 3: 307–12. PMID 9209374.
- Wadman, I. A.; Osada, H; Grütz, GG; Agulnick, AD; Westphal, H; Forster, A; Rabbitts, TH (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins". The EMBO Journal 16 (11): 3145–57. doi:10.1093/emboj/16.11.3145. PMC 1169933. PMID 9214632.
- Visvader, J. E. (1997). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation". Proceedings of the National Academy of Sciences 94 (25): 13707–12. doi:10.1073/pnas.94.25.13707. PMC 28370. PMID 9391090.
- Jurata, L. W.; Pfaff, SL; Gill, GN (1998). "The Nuclear LIM Domain Interactor NLI Mediates Homo- and Heterodimerization of LIM Domain Transcription Factors". Journal of Biological Chemistry 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.
- Kenny, D. A. (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proceedings of the National Academy of Sciences 95 (19): 11257–62. doi:10.1073/pnas.95.19.11257. PMC 21629. PMID 9736723.
- Ono, Y; Fukuhara, N; Yoshie, O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Molecular and Cellular Biology 18 (12): 6939–50. PMC 109277. PMID 9819382.
- Bach, Ingolf; Belmonte, Juan Carlos Izpisúa; Rosenfeld, Michael G.; Rodriguez-Esteban, Concepción; Carrière, Catherine; Bhushan, Anil; Krones, Anna; Rose, David W. et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nature Genetics 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.
- Vitelli, L.; Condorelli, G.; Lulli, V.; Hoang, T.; Luchetti, L.; Croce, C. M.; Peschle, C. (2000). "A Pentamer Transcriptional Complex Including tal-1 and Retinoblastoma Protein Downmodulates c-kit Expression in Normal Erythroblasts". Molecular and Cellular Biology 20 (14): 5330–42. doi:10.1128/MCB.20.14.5330-5342.2000. PMC 85982. PMID 10866689.
- Davenport, J; Neale, G A M; Goorha, R (2000). "Identification of genes potentially involved in LMO2-induced leukemogenesis". Leukemia 14 (11): 1986–96. doi:10.1038/sj.leu.2401913. PMID 11069036.
- Sum, E. Y. M. (2001). "The LIM Domain Protein LMO4 Interacts with the Cofactor CtIP and the Tumor Suppressor BRCA1 and Inhibits BRCA1 Activity". Journal of Biological Chemistry 277 (10): 7849–5. doi:10.1074/jbc.M110603200. PMID 11751867.