LIPH

From Wikipedia, the free encyclopedia

"LIPH" is also the ICAO code for Treviso Airport.

Lipase, member H

Identifiers

LIPH; AH; ARWH2; LAH2; LPDLR; PLA1B; mPA-PLA1

External IDs

OMIM: 607365 MGI: 2388029 HomoloGene: 71802 GeneCards: LIPH Gene

Gene Ontology
Molecular function	• phospholipase activity • heparin binding
Cellular component	• extracellular space • plasma membrane
Biological process	• lipid catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000163898

ENSMUSG00000044626

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
185.22 – 185.27 Mb

Chr 16:
21.95 – 22 Mb

PubMed search

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.^[1]^[2]^[3]

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.^[3]

References

↑ Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.
↑ Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID 12063250.
↑ 3.0 3.1 "Entrez Gene: LIPH lipase, member H".

Further reading

Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wen XY, Hegele RA, Wang J et al. (2004). "Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans". Hum. Mol. Genet. 12 (10): 1131–43. doi:10.1093/hmg/ddg124. PMID 12719377.
Hiramatsu T, Sonoda H, Takanezawa Y et al. (2004). "Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta". J. Biol. Chem. 278 (49): 49438–47. doi:10.1074/jbc.M213018200. PMID 12963729.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Aslam M, Chahrour MH, Razzaq A et al. (2005). "A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33–q27.3". J. Med. Genet. 41 (11): 849–52. doi:10.1136/jmg.2004.019729. PMC 1735610. PMID 15520410.
Kazantseva A, Goltsov A, Zinchenko R et al. (2006). "Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH". Science 314 (5801): 982–5. doi:10.1126/science.1133276. PMID 17095700.
Ali G, Chishti MS, Raza SI et al. (2007). "A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis". Hum. Genet. 121 (3–4): 319–25. doi:10.1007/s00439-007-0344-0. PMID 17333281.

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.