LINGO1
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| Leucine rich repeat and Ig domain containing 1 | |||||||||||||
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 PDB rendering based on 2id5. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | LINGO1; LERN1; LRRN6A; UNQ201 | ||||||||||||
| External IDs | OMIM: 609791 MGI: 1915522 HomoloGene: 41891 GeneCards: LINGO1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 84894 | 235402 | |||||||||||
| Ensembl | ENSG00000169783 | ENSMUSG00000049556 | |||||||||||
| UniProt | Q96FE5 | Q9D1T0 | |||||||||||
| RefSeq (mRNA) | NM_032808 | NM_181074 | |||||||||||
| RefSeq (protein) | NP_116197 | NP_851419 | |||||||||||
| Location (UCSC) | Chr 15: 77.91 – 78.11 Mb | Chr 9: 56.62 – 56.69 Mb | |||||||||||
| PubMed search | |||||||||||||
Leucine rich repeat and Ig domain containing 1 also known as LINGO-1 is a protein which in humans is encoded by the LINGO1 gene.[1][2]
Structure
LINGO-1 contains an N-terminal leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail.[2][3]
LINGO-1 interacts with the Nogo receptor.[3]
Function
LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and p75 (signal transducing subunit). The inhibitory action is achieved through RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system.[3] LINGO-1 also inhibits oligodendrocyte precursor differentiation and myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require 75 or NgR1.
References
- ↑ "Entrez Gene: LINGO1 leucine rich repeat and Ig domain containing 1".
- ↑ 2.0 2.1 Carim-Todd L, Escarceller M, Estivill X, Sumoy L (December 2003). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". Eur. J. Neurosci. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891.
- ↑ 3.0 3.1 3.2 Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB (March 2004). "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex". Nat. Neurosci. 7 (3): 221–8. doi:10.1038/nn1188. PMID 14966521.
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Carim-Todd L, Escarceller M, Estivill X, Sumoy L (2004). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex". Eur. J. Neurosci. 18 (12): 3167–82. doi:10.1111/j.1460-9568.2003.03003.x. PMID 14686891.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Mi S, Lee X, Shao Z et al. (2004). "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex". Nat. Neurosci. 7 (3): 221–8. doi:10.1038/nn1188. PMID 14966521.
- Shao Z, Browning JL, Lee X et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration". Neuron 45 (3): 353–9. doi:10.1016/j.neuron.2004.12.050. PMID 15694322.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mosyak L, Wood A, Dwyer B et al. (2007). "The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition". J. Biol. Chem. 281 (47): 36378–90. doi:10.1074/jbc.M607314200. PMID 17005555.
- Satoh J, Tabunoki H, Yamamura T et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol. 33 (1): 99–107. doi:10.1111/j.1365-2990.2006.00787.x. PMID 17239012.
- Inoue H, Lin L, Lee X et al. (2007). "Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14430–5. doi:10.1073/pnas.0700901104. PMC 1955463. PMID 17726113.
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