KvLQT3

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Potassium voltage-gated channel, KQT-like subfamily, member 3
Identifiers
SymbolsKCNQ3; BFNC2; EBN2; KV7.3
External IDsOMIM: 602232 MGI: 1336181 HomoloGene: 20949 IUPHAR: Kv7.3 ChEMBL: 2684 GeneCards: KCNQ3 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez3786110862
EnsemblENSG00000184156ENSMUSG00000056258
UniProtO43525Q8K3F6
RefSeq (mRNA)NM_001204824NM_152923
RefSeq (protein)NP_001191753NP_690887
Location (UCSC)Chr 8:
133.14 – 133.49 Mb
Chr 15:
66 – 66.29 Mb
PubMed search

Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.[1]

It is associated with benign familial neonatal epilepsy.

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).[1]

Interactions

KvLQT3 has been shown to interact with KCNQ5.[2]

References

  1. 1.0 1.1 "Entrez Gene: KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3". 
  2. Yus-Nájera, E; Muñoz A, Salvador N, Jensen B S, Rasmussen H B, Defelipe J, Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience (United States) 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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