KLF9
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| Kruppel-like factor 9 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KLF9; BTEB; BTEB1 | ||||||||||||
| External IDs | OMIM: 602902 MGI: 1333856 HomoloGene: 931 GeneCards: KLF9 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 687 | 16601 | |||||||||||
| Ensembl | ENSG00000119138 | ENSMUSG00000033863 | |||||||||||
| UniProt | Q13886 | O35739 | |||||||||||
| RefSeq (mRNA) | NM_001206 | NM_010638 | |||||||||||
| RefSeq (protein) | NP_001197 | NP_034768 | |||||||||||
| Location (UCSC) | Chr 9: 73 – 73.03 Mb | Chr 19: 23.14 – 23.17 Mb | |||||||||||
| PubMed search | |||||||||||||
Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene.[1][2]
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription.[2]
Interactions
KLF9 has been shown to interact with Progesterone receptor.[3]
References
- ↑ Imataka H, Sogawa K, Yasumoto K, Kikuchi Y, Sasano K, Kobayashi A, Hayami M, Fujii-Kuriyama Y (Nov 1992). "Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene". EMBO J 11 (10): 3663–71. PMC 556826. PMID 1356762.
- ↑ 2.0 2.1 "Entrez Gene: KLF9 Kruppel-like factor 9".
- ↑ Zhang, Xue-Lian; Zhang Daying, Michel Frank J, Blum Jason L, Simmen Frank A, Simmen Rosalia C M (Jun 2003). "Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells". J. Biol. Chem. (United States) 278 (24): 21474–82. doi:10.1074/jbc.M212098200. ISSN 0021-9258. PMID 12672823.
Further reading
- Kobayashi A, Sogawa K, Imataka H, Fujii-Kuriyama Y (1995). "Analysis of functional domains of a GC box-binding protein, BTEB". J. Biochem. 117 (1): 91–5. PMID 7775404.
- Imataka H, Nakayama K, Yasumoto K et al. (1994). "Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region". J. Biol. Chem. 269 (32): 20668–73. PMID 8051167.
- Imataka H, Mizuno A, Fujii-Kuriyama Y, Hayami M (1994). "Activation of the human immunodeficiency virus type 1 long terminal repeat by BTEB, a GC box-binding transcription factor". AIDS Res. Hum. Retroviruses 9 (9): 825–31. doi:10.1089/aid.1993.9.825. PMID 8257632.
- Hashimoto H, Toide K, Kitamura R et al. (1994). "Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control". Eur. J. Biochem. 218 (2): 585–95. doi:10.1111/j.1432-1033.1993.tb18412.x. PMID 8269949.
- Ohe N, Yamasaki Y, Sogawa K et al. (1994). "Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein". Somat. Cell Mol. Genet. 19 (5): 499–503. doi:10.1007/BF01233255. PMID 8291025.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang XL, Zhang D, Michel FJ et al. (2003). "Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells". J. Biol. Chem. 278 (24): 21474–82. doi:10.1074/jbc.M212098200. PMID 12672823.
- Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Velarde MC, Iruthayanathan M, Eason RR et al. (2006). "Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1". Endocrinology 147 (4): 1969–78. doi:10.1210/en.2005-1419. PMID 16384861.
External links
- KLF9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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