KIFC1

From Wikipedia, the free encyclopedia

Kinesin family member C1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2REP

Identifiers

KIFC1; HSET; KNSL2

External IDs

OMIM: 603763 MGI: 109596 HomoloGene: 83229 GeneCards: KIFC1 Gene

Gene Ontology
Molecular function	• microtubule motor activity • ATP binding
Cellular component	• nucleus • early endosome • microtubule organizing center • spindle • microtubule • microtubule associated complex
Biological process	• mitotic sister chromatid segregation • microtubule-based movement • blood coagulation • cell division
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000056678

ENSMUSG00000024301

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
33.36 – 33.38 Mb

Chr 17:
26.92 – 26.93 Mb

PubMed search

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.^[1]^[2]

The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.

References

↑ Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics 39 (3): 194–200. PMID 8276466.
↑ "Entrez Gene: KIFC1 kinesin family member C1".

Further reading

Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
Janitz K, Wild A, Beck S et al. (1999). "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)". Immunogenetics 49 (7–8): 644–52. doi:10.1007/s002510050660. PMID 10369922.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Neef R, Preisinger C, Sutcliffe J et al. (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis". J. Cell Biol. 162 (5): 863–75. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gruneberg U, Neef R, Honda R et al. (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Al-Bassam J, Roger B, Halpain S, Milligan RA (2007). "Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c". Cell Motil. Cytoskeleton 64 (5): 377–89. doi:10.1002/cm.20190. PMID 17326138.

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