KCNJ9
From Wikipedia, the free encyclopedia
| Potassium inwardly-rectifying channel, subfamily J, member 9 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KCNJ9; GIRK3; KIR3.3 | ||||||||||||
| External IDs | OMIM: 600932 MGI: 108007 HomoloGene: 37989 IUPHAR: Kir3.3 GeneCards: KCNJ9 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3765 | 16524 | |||||||||||
| Ensembl | ENSG00000162728 | ENSMUSG00000038026 | |||||||||||
| UniProt | Q92806 | P48543 | |||||||||||
| RefSeq (mRNA) | NM_004983 | NM_008429 | |||||||||||
| RefSeq (protein) | NP_004974 | NP_032455 | |||||||||||
| Location (UCSC) | Chr 1: 160.05 – 160.06 Mb | Chr 1: 172.32 – 172.33 Mb | |||||||||||
| PubMed search | |||||||||||||
G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.[1][2][3]
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.[3]
Interactions
KCNJ9 has been shown to interact with KCNJ6.[4][5]
See also
References
- ↑ Lesage F, Fink M, Barhanin J, Lazdunski M, Mattei MG (March 1996). "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23". Genomics 29 (3): 808–9. doi:10.1006/geno.1995.9928. PMID 8575783.
- ↑ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
- ↑ 3.0 3.1 "Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9".
- ↑ Jelacic, T M; Kennedy M E, Wickman K, Clapham D E (November 2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". J. Biol. Chem. (UNITED STATES) 275 (46): 36211–6. doi:10.1074/jbc.M007087200. ISSN 0021-9258. PMID 10956667.
- ↑ Lavine, Natalie; Ethier Nathalie, Oak James N, Pei Lin, Liu Fang, Trieu Phan, Rebois R Victor, Bouvier Michel, Hebert Terence E, Van Tol Hubert H M (November 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. (United States) 277 (48): 46010–9. doi:10.1074/jbc.M205035200. ISSN 0021-9258. PMID 12297500.
Further reading
- Jelacic TM, Sims SM, Clapham DE (1999). "Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3". J. Membr. Biol. 169 (2): 123–9. doi:10.1007/s002329900524. PMID 10341034.
- Schoots O, Wilson JM, Ethier N, et al. (2000). "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cell. Signal. 11 (12): 871–83. doi:10.1016/S0898-6568(99)00059-5. PMID 10659995.
- Vaughn J, Wolford JK, Prochazka M, Permana PA (2000). "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)". Biochem. Biophys. Res. Commun. 274 (2): 302–9. doi:10.1006/bbrc.2000.3136. PMID 10913335.
- Jelacic TM, Kennedy ME, Wickman K, Clapham DE (2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3". J. Biol. Chem. 275 (46): 36211–6. doi:10.1074/jbc.M007087200. PMID 10956667.
- Lavine N, Ethier N, Oak JN, et al. (2003). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
- Plummer HK, Dhar MS, Cekanova M, Schuller HM (2006). "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines". BMC Cancer 5: 104. doi:10.1186/1471-2407-5-104. PMC 1208863. PMID 16109170.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
External links
- KCNJ9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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