Janeway lesion

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Janeway lesion
Classification and external resources
ICD-10 A41.8 (ILDS A41.820)

Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are indicative of infective endocarditis.[1] Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis.[1] They are caused by septic emboli which deposit bacteria, forming microabscesses.[2] Janeway lesions are distal, flat, ecchymotic, and painless.

Osler's nodes and Janeway lesions are similar, but Osler's nodes present with tenderness and are of immunologic origin.[3]

Eponym

They are named after Theodore Caldwell Janeway (1872–1917), an American professor of medicine with interests in cardiology and infectious disease.[4]

See also

References

  1. ↑ 1.0 1.1 Farrior, J.B.; Silverman M.E. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688. 
  2. ↑ Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed., Churchill Livingstone 2009.
  3. ↑ Farrior JB, Silverman ME (August 1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688. 
  4. ↑ Janeway C. (1998). "Presidential Address to The American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response". J. Immunol. 161 (2): 539–44. PMID 9670925. 

Supporting images

Eponymous medical signs for circulatory system
Heart disease
Heart murmur
Aortic insufficiency
Other endocardium
Pericardium
Other
Vascular disease
Arterial
Venous

M: HRT

anat/phys/devp

noco/cong/tumr, sysi/epon, injr

proc, drug (C1A/1B/1C/1D), blte

M: VAS

anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug (C2s+n/3/4/5/7/8/9)

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