James Robins

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Robins at the Mathematical Research Institute of Oberwolfach in 2012

James M. Robins is an epidemiologist and biostatistician best known for advancing methods for drawing causal inferences from complex observational studies and randomized trials, particularly those in which the treatment varies with time. He is the 2013 recipient of the Nathan Mantel Award for lifetime achievement in statistics and epidemiology.

He graduated in medicine from Washington University in 1976. He is currently Mitchell L. and Robin LaFoley Dong Professor of Epidemiology at Harvard School of Public Health. He has published over 100 papers in academic journals and is an ISI highly cited researcher.[1]

Biography

James Robins attended Harvard College with the class of 1971, concentrating in mathematics and philosophy. He was elected to Phi Beta Kappa in his junior year, but did not graduate. He went on to attend Washington University School of Medicine, and practiced Occupational Medicine for several years. While working in occupational medicine, he attended basic courses in applied medical statistics at the Yale School of Public Health, but quickly came to the realization that the methodology used at the time was insufficiently rigorous to support causal conclusions.

Research

In 1986, Robins published the paper "A New Approach to Causal Inference in Mortality Studies", which introduced a new framework for drawing causal inference from observational data. In this paper and in other articles published around the same time, Robins showed that in non-experimental data, exposure is almost always time-dependent, and that standard methods such as regression are therefore almost always biased. This framework is mathematically very closely related to Judea Pearl's graphical framework Non-Parametric Structural Equations Models, which Pearl developed independently around the same time.

In his original paper on causal inference, Robins described two new methods for controlling for confounding bias, which can be applied in the generalized setting of time-dependent exposures: The G-formula and G-Estimation of Structural Nested Models. Later, he introduced a third class of models, Marginal Structural Models, in which the parameters are estimated using inverse probability of treatment weights. These three methods for controlling for confounding are mathematically equivalent when used non-parametrically, but each suggests a different type of modelling assumptions on the joint distribution of the variables. He has also contributed significantly to the theory of dynamic treatment regimes, which are of high significance in comparative effectiveness research and personalized medicine.


Notes

  1. ↑ Robins, James at ISIHighlyCited.com

References

Selected publications

  • Robins, J.M. (1989). "The control of confounding by intermediate variables". Statistics in Medicine 8 (6): 679–701. doi:10.1002/sim.4780080608. PMID 2749074. 
  • Robins, J.M.; Tsiatis, A.A. (1991). "Correcting for non-compliance in randomized trials using rank preserving structural failure time models". Communications in Statistics - Theory and Methods 20 (8): 2609–2631. doi:10.1080/03610929108830654. 
  • Robins, J.M. (1994). "Correcting for non-compliance in randomized trials using structural nested mean models". Communications in Statistics - Theory and Methods 23 (8): 2379–2412. doi:10.1080/03610929408831393. 
  • Robins, J.M. (1997). "Causal inference from complex longitudinal data". In M. Berkane. Latent Variable Modeling and Applications to Causality. Lecture notes in statistics 120. Springer-Verlag. pp. 69–117. 
  • Robins, J.M.; Ritov, Y. (1997). "Toward A Curse Of Dimensionality Appropriate (CODA) Asymptotic Theory For Semi-parametric Models". Statistics in Medicine 16 (3): 285–319. doi:10.1002/(SICI)1097-0258(19970215)16:3<285::AID-SIM535>3.3.CO;2-R. PMID 9004398. 
  • Robins, J.M. (1998). "Correction for non-compliance in equivalence trials". Statistics in Medicine 17 (3): 269–302. doi:10.1002/(SICI)1097-0258(19980215)17:3<269::AID-SIM763>3.0.CO;2-J. PMID 9493255. 
  • Robins, J.M.; Hernan, M.A.; Brumback, B. (2000). "Marginal Structural Models and Causal Inference in Epidemiology". Epidemiology 11 (5): 550–560. doi:10.1097/00001648-200009000-00011. JSTOR 3703997. PMID 10955408. 
  • Van Der Laan, M.J.; Robins, J.M. (2003). Unified Methods for Censored Longitudinal Data and Causality. Springer Series in Statistics. Springer. ISBN 0-387-95556-9. 
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