JX-594

From Wikipedia, the free encyclopedia

JX-594 is an oncolytic virus (also known as Pexa-Vec[1]) developed by Jennerex and partners: Transgene S.A.; Lee's Pharmaceutical Holdings Ltd.; and Green Cross Corp. Pexa-Vec is designed to target and destroy cancer cells.[2]

JX-594 is a vaccinia poxvirus engineered by addition of the GM-CSF gene and deletion of the thymidine kinase gene which limits viral replication to cells with high levels of thymidine kinase, typically seen in cancer cells with a mutated RAS or p53 gene.[3] The virus kills them by lysis and also expresses GM-CSF which may help initiate an anti-tumour immune response.[4][5] [6]

It has orphan drug designation from US FDA and EUMA for the treatment of hepatocellular carcinoma (HCC).[1]

Clinical trials

Two Phase I trials have reported results and a phase II trial for primary liver cancer, alone and in combination with sorafenib is starting.[5]

JX-594[7] Phase I results in 23 patients had encouraging results in 6 of 8 high dosed patients.[8]

Early results, in Nov 2011, from a small (30 patient) phase II trial in advanced hepatocellular carcinoma (HCC) showed an increased median overall survival of 13.8 months compared 6.7 months for a lower dose (p=0.029).[9]

See also

References

  1. ↑ 1.0 1.1 Jennerex Granted FDA Orphan Drug Designation for Pexa-Vec in Hepatocellular Carcinoma (HCC)
  2. ↑ Un virus contre le cancer 25 March 2012, Radio Canada (French)
  3. ↑ Bos, JL (Sep 1, 1989). "ras oncogenes in human cancer: a review.". Cancer research 49 (17): 4682–9. PMID 2547513. 
  4. ↑ "NCI Drug Dictionary". National Cancer Institute. Retrieved 25 March 2013. 
  5. ↑ 5.0 5.1 "Novel Cancer-Targeting Virus Therapy Shows Efficacy in Early-Stage Trial". 31 August 2011. 
  6. ↑ Breitbach at al. (2011). Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans 477 (7362). doi:10.1038/nature10358. PMID 21886163. 
  7. ↑ http://www.voanews.com/english/news/health/Cancer-Fighting-Engineered-Virus-Makes-Medical-History-128899673.html September 01, 2011 Voice of America
  8. ↑ "Cancer-fighting virus shown to target tumors alone". Aug 31, 2011. 
  9. ↑ "AASLD: Virus Shuts Down Liver Cancer in Early Trials". Nov 2011. 

External links

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