JUB (gene)
From Wikipedia, the free encyclopedia
Protein ajuba is a protein that in humans is encoded by the JUB gene.[1][2]
JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.
Interactions
JUB (gene) has been shown to interact with Stratifin[3] and SLC1A2.[4]
References
- ↑ Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD (Jun 1999). "Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner". Mol Cell Biol 19 (6): 4379–89. PMC 104397. PMID 10330178.
- ↑ "Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)".
- ↑ Benzinger, Anne; Muster Nemone, Koch Heike B, Yates John R, Hermeking Heiko (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics (United States) 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. ISSN 1535-9476. PMID 15778465.
- ↑ Marie, Hélène; Billups Daniela, Bedford Fiona K, Dumoulin Andrea, Goyal Rakesh K, Longmore Gregory D, Moss Stephen J, Attwell David (Feb 2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. (United States) 19 (2): 152–64. doi:10.1006/mcne.2001.1066. ISSN 1044-7431. PMID 11860269.
Further reading
- Kanungo J, Pratt SJ, Marie H, Longmore GD (2000). "Ajuba, a Cytosolic LIM Protein, Shuttles into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions". Mol. Biol. Cell 11 (10): 3299–313. PMC 14993. PMID 11029037.
- Marie H, Billups D, Bedford FK, et al. (2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. 19 (2): 152–64. doi:10.1006/mcne.2001.1066. PMID 11860269.
- Marie H, Pratt SJ, Betson M, et al. (2003). "The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin". J. Biol. Chem. 278 (2): 1220–8. doi:10.1074/jbc.M205391200. PMID 12417594.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hirota T, Kunitoku N, Sasayama T, et al. (2003). "Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells". Cell 114 (5): 585–98. doi:10.1016/S0092-8674(03)00642-1. PMID 13678582.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Pratt SJ, Epple H, Ward M, et al. (2005). "The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration". J. Cell Biol. 168 (5): 813–24. doi:10.1083/jcb.200406083. PMC 2171823. PMID 15728191.
- Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Kisseleva M, Feng Y, Ward M, et al. (2005). "The LIM Protein Ajuba Regulates Phosphatidylinositol 4,5-Bisphosphate Levels in Migrating Cells through an Interaction with and Activation of PIPKIα". Mol. Cell. Biol. 25 (10): 3956–66. doi:10.1128/MCB.25.10.3956-3966.2005. PMC 1087706. PMID 15870270.
- Feng Y, Longmore GD (2005). "The LIM Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ/p62/TRAF6 Signaling Complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25.10.4010-4022.2005. PMC 1087715. PMID 15870274.
- Abe Y, Ohsugi M, Haraguchi K, et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 (3): 782–8. doi:10.1016/j.febslet.2005.12.096. PMID 16413547.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008). "TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours". Mol. Cell Endocrinol. 306 (1–2): 75–80. doi:10.1016/j.mce.2008.10.043. PMID 19041365.
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