Isoliquiritigenin

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Isoliquiritigenin
Identifiers
CAS number 961-29-5 YesY
PubChem 638278
ChEBI CHEBI:310312 N
ChEMBL CHEMBL129795 N
Jmol-3D images Image 1
Properties
Molecular formula C15H12O4
Molar mass 256.25 g/mol
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Isoliquiritigenin is a licorice chalconoid, a type of natural phenols. It is under experimentation phase testing for use as a cancer treatment and as an aide for cocaine addiction. It is a sirtuin-activating compound.

Metabolism

The enzyme 6'-deoxychalcone synthase uses malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H+ to produce CoA, isoliquiritigenin, CO2, NADP+, and H2O.

The enzyme isoliquiritigenin 2'-O-methyltransferase further transforms isoliquiritigenin into 2'-O-methylisoliquiritigenin.

Mechanism of action

Isoliquiritigenin has been found to potent (65 times higher affinity than diazepine) GABA-A benzodiapine receptor positive allosteric modulator.[1]

References

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