Isoliquiritigenin
Isoliquiritigenin | ||
---|---|---|
IUPAC name (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one | ||
Other names 6'-deoxychalcone | ||
Identifiers | ||
CAS number | 961-29-5 | |
PubChem | 638278 | |
ChEBI | CHEBI:310312 | |
ChEMBL | CHEMBL129795 | |
Jmol-3D images | Image 1 | |
| ||
Properties | ||
Molecular formula | C15H12O4 | |
Molar mass | 256.25 g/mol | |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | ||
Infobox references | ||
Isoliquiritigenin is a licorice chalconoid, a type of natural phenols. It is under experimentation phase testing for use as a cancer treatment and as an aide for cocaine addiction. It is a sirtuin-activating compound.
Metabolism
The enzyme 6'-deoxychalcone synthase uses malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H+ to produce CoA, isoliquiritigenin, CO2, NADP+, and H2O.
The enzyme isoliquiritigenin 2'-O-methyltransferase further transforms isoliquiritigenin into 2'-O-methylisoliquiritigenin.
Mechanism of action
Isoliquiritigenin has been found to potent (65 times higher affinity than diazepine) GABA-A benzodiapine receptor positive allosteric modulator.[1]
References
|