Isocitric acid
Isocitric acid | |
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IUPAC name 1-Hydroxypropane-1,2,3-tricarboxylic acid | |
Identifiers | |
CAS number | 320-77-4 |
PubChem | 1198 |
ChemSpider | 1161 |
DrugBank | DB01727 |
KEGG | C00311 |
MeSH | Isocitrate |
ChEBI | CHEBI:30887 |
ChEMBL | CHEMBL539669 |
Jmol-3D images | Image 1 |
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Properties | |
Molecular formula | C6H8O7 |
Molar mass | 192.12 g mol−1 |
Melting point | 105 °C |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
Infobox references | |
Isocitric acid is a protonated form of isocitrate, which is a substrate of the citric acid cycle. Isocitrate is formed from citrate with the help of the enzyme aconitase, and is acted upon by isocitrate dehydrogenase. Salts and esters of isocitric acid are known as isocitrates.
Isocitric acid is commonly used as a marker to detect the authenticity and quality of fruit products, most often citrus juices. In authentic orange juice, for example, the ratio of citric acid to D-isocitric acid is usually less than 130. An isocitric acid value higher than this may be indicative of fruit juice adulteration.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
- ↑ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".
References
Citric Acid Cycle Metabolic Pathway | ||||||||||||||||||
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Oxaloacetate | Malate | Fumarate | Succinate | Succinyl-CoA | ||||||||||||||
Acetyl-CoA | NADH + H+ | NAD+ | H2O | FADH2 | FAD | CoA + ATP(GTP) | Pi + ADP(GDP) | |||||||||||
+ | H2O | NADH + H+ + CO2 | ||||||||||||||||
CoA | NAD+ | |||||||||||||||||
H2O | H2O | NAD(P)+ | NAD(P)H + H+ | CO2 | ||||||||||||||
Citrate | cis-Aconitate | Isocitrate | Oxalosuccinate | α-Ketoglutarate | ||||||||||||||
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