Ipriflavone
From Wikipedia, the free encyclopedia
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|---|---|
| Systematic (IUPAC) name | |
| 7-isopropoxy-3-phenyl-4H-chromen-4-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Legal status | ? |
| Identifiers | |
| CAS number | 35212-22-7  |
| ATC code | M05BX01 |
| PubChem | CID 3747 |
| UNII | 80BJ7WN25Z  |
| KEGG | D01338 |
| ChEMBL | CHEMBL165790 |
| Synonyms | 3-phenyl-7-propan-2-yloxychromen-4-one |
| Chemical data | |
| Formula | C18H16O3 |
| Mol. mass | 280.318 g/mol |
| (what is this?) (verify) | |
Ipriflavone is a synthetic isoflavone which may be used to inhibit bone resorption,[1] maintain bone density and to prevent osteoporosis in postmenopausal women. It is not used to treat osteoporosis. It slows down the action of the osteoclasts (bone-eroding cells), possibly allowing the osteoblasts (bone-building cells) to build up bone mass.
A clinical trial reported in 2001 that it was not effective in prevention or treatment of osteoporosis.[2]
A double-blind study reveals that ipriflavone might be effective on reducing tinnitus on otosclerosis sufferers.[3]
References
- ↑ Civitelli, R. (1997). "In Vitro and in Vivo effects of ipriflavone on bone formation and bone biomechanics". Calcified Tissue International 61: S12–4. doi:10.1007/s002239900378. PMID 9263610.
- ↑ Alexandersen, P.; Toussaint, A; Christiansen, C; Devogelaer, JP; Roux, C; Fechtenbaum, J; Gennari, C; Reginster, JY; Ipriflavone Multicenter European Fracture Study (2001). "Ipriflavone in the Treatment of Postmenopausal Osteoporosis: A Randomized Controlled Trial". JAMA 285 (11): 1482–8. doi:10.1001/jama.285.11.1482. PMID 11255425.
- ↑ Sziklai, I; Komora, V; Ribári, O (1992). "Double-blind study on the effectiveness of a bioflavonoid in the control of tinnitus in otosclerosis". Acta chirurgica Hungarica 33 (1–2): 101–7. PMID 1343452.
External links
- Ipriflavone at PDR Health
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