Internalin

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Internalins are surface proteins found on Listeria monocytogenes. They exist in two known forms, InlA and InlB. They are used by the bacteria to invade mammalian cells via cadherins transmembrane proteins. The exact role of these proteins and their invasiveness in vivo is not completely understood. In cultured cells, InlA is necessary to facilitate Listeria entry into human epithelial cells. While InlB is necessary for Listeria internalisation in several other cell types, including hepatocytes, fibroblasts, and epithelioid cells.[1]

See also

References

  1. ↑ Lecuit M, Ohayon H, Braun L, Mengaud J, Cossart P. (1997). "Internalin of Listeria monocytogenes with an intact leucine-rich repeat region is sufficient to promote internalization". Infect Immun. 65 (12): 5309–19. PMC 175764. PMID 9393831. 


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