Interleukin 24
| Interleukin 24 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | IL24; C49A; FISP; IL10B; MDA7; MOB5; ST16 | ||||||||||||
| External IDs | OMIM: 604136 MGI: 2135548 HomoloGene: 4991 GeneCards: IL24 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11009 | 93672 | |||||||||||
| Ensembl | ENSG00000162892 | ENSMUSG00000026420 | |||||||||||
| UniProt | Q13007 | Q925S4 | |||||||||||
| RefSeq (mRNA) | NM_001185156 | NM_053095 | |||||||||||
| RefSeq (protein) | NP_001172085 | NP_444325 | |||||||||||
| Location (UCSC) | Chr 1: 207.07 – 207.08 Mb | Chr 1: 130.88 – 130.89 Mb | |||||||||||
| PubMed search | |||||||||||||
Interleukin 24 (IL-24) is a protein that in humans is encoded by the IL24 gene.
IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells[1] and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.[2] Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.[3][4] The gene for IL-24 is located on chromosome 1 in humans.[5]
References
- ↑ Poindexter NJ, Walch ET, Chada S, Grimm EA (September 2005). "Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells". J. Leukoc. Biol. 78 (3): 745–52. doi:10.1189/jlb.0205116. PMID 16000394.
- ↑ Wang M, Liang P (February 2005). "Interleukin-24 and its receptors". Immunology 114 (2): 166–70. doi:10.1111/j.1365-2567.2005.02094.x. PMC 1782067. PMID 15667561.
- ↑ Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P (2003). "mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic". Cancer Biol. Ther. 2 (4 Suppl 1): S23–37. PMID 14508078.
- ↑ Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB (May 2004). "Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways". Cancer Res. 64 (9): 2988–93. doi:10.1158/0008-5472.CAN-04-0200. PMID 15126330.
- ↑ IL24 GeneCard
External links
Interleukin24 bibliography of open articles and PubMed search term
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