Interleukin 1 receptor, type II
From Wikipedia, the free encyclopedia
| Interleukin 1 receptor, type II | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | IL1R2; CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2c; IL1RB | ||||||||||||
| External IDs | OMIM: 147811 MGI: 96546 HomoloGene: 7783 GeneCards: IL1R2 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7850 | 16178 | |||||||||||
| Ensembl | ENSG00000115590 | ENSMUSG00000026073 | |||||||||||
| UniProt | P27930 | P27931 | |||||||||||
| RefSeq (mRNA) | NM_001261419 | NM_010555 | |||||||||||
| RefSeq (protein) | NP_001248348 | NP_034685 | |||||||||||
| Location (UCSC) | Chr 2: 102.61 – 102.65 Mb | Chr 1: 40.08 – 40.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[1]
See also
References
Further reading
- McMahan CJ, Slack JL, Mosley B et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. PMC 452992. PMID 1833184.
- Dripps DJ, Verderber E, Ng RK et al. (1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". J. Biol. Chem. 266 (30): 20311–5. PMID 1834644.
- Fasano MB, Cousart S, Neal S, McCall CE (1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". J. Clin. Invest. 88 (5): 1452–9. doi:10.1172/JCI115454. PMC 295647. PMID 1834697.
- Sadouk MB, Pelletier JP, Tardif G et al. (1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Lab. Invest. 73 (3): 347–55. PMID 7564267.
- Symons JA, Young PR, Duff GW (1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1714–8. doi:10.1073/pnas.92.5.1714. PMC 42590. PMID 7878046.
- Arend WP, Malyak M, Smith MF et al. (1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". J. Immunol. 153 (10): 4766–74. PMID 7963543.
- Giri JG, Wells J, Dower SK et al. (1995). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". J. Immunol. 153 (12): 5802–9. PMID 7989776.
- Re F, Muzio M, De Rossi M et al. (1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". J. Exp. Med. 179 (2): 739–43. doi:10.1084/jem.179.2.739. PMC 2191363. PMID 8294881.
- Colotta F, Re F, Muzio M et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science 261 (5120): 472–5. doi:10.1126/science.8332913. PMID 8332913.
- Sambo P, Fadlon EJ, Sironi M et al. (1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood 87 (5): 1682–6. PMID 8634411.
- Larregina A, Morelli A, Kolkowski E, Fainboim L (1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology 87 (2): 317–25. doi:10.1046/j.1365-2567.1996.451513.x. PMC 1384291. PMID 8698397.
- Liu C, Hart RP, Liu XJ et al. (1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". J. Biol. Chem. 271 (34): 20965–72. doi:10.1074/jbc.271.34.20965. PMID 8702856.
- Colotta F, Saccani S, Giri JG et al. (1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". J. Immunol. 156 (7): 2534–41. PMID 8786316.
- Sébire G, Delfraissy JF, Demotes-Mainard J et al. (1997). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine 8 (8): 636–41. doi:10.1006/cyto.1996.0085. PMID 8894439.
- Lovenberg TW, Crowe PD, Liu C et al. (1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J. Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.
- van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". J. Infect. Dis. 175 (1): 118–22. doi:10.1093/infdis/175.1.118. PMID 8985204.
- Rauschmayr T, Groves RW, Kupper TS (1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5814–9. doi:10.1073/pnas.94.11.5814. PMC 20863. PMID 9159157.
- Gomez E, Morel G, Cavalier A et al. (1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biol. Reprod. 56 (6): 1513–26. doi:10.1095/biolreprod56.6.1513. PMID 9166705.
- Cannon JG, Angel JB, Abad LW et al. (1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". J. Clin. Immunol. 17 (3): 253–61. doi:10.1023/A:1027314713231. PMID 9168406.
- Fink GW, Norman JG (1998). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine 9 (12): 1023–7. doi:10.1006/cyto.1997.0260. PMID 9417814.
External links
- IL1R2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| |||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.