Indobufen

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Indobufen


Systematic (IUPAC) name
2-(4-(1-Oxoisoindolin-2-yl)phenyl)butanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	63610-08-2^Y
ATC code	B01AC10
PubChem	CID 107641
ChemSpider	96823^N
UNII	6T9949G4LZ^Y
KEGG	D07141^Y
ChEMBL	CHEMBL1765292^N
Chemical data
Formula	C₁₈H₁₇N O₃
Mol. mass	295.333 g/mol
SMILES O=C(O)C(c1ccc(cc1)N3C(=O)c2ccccc2C3)CC
InChI InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22)^N Key:AYDXAULLCROVIT-UHFFFAOYSA-N^N
N (what is this?) (verify)

Indobufen is a platelet aggregation inhibitor.^[1] It acts as a reversible cyclooxygenase inhibitor.^[2]

References

↑ The Merck Index, 12th Edition. 4991
↑ Eligini, Sonia; Violi, F; Banfi, C; Barbieri, SS; Brambilla, M; Saliola, M; Tremoli, E; Colli, S (2005). "Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism". Cardiovascular Research 69 (1): 218–226. doi:10.1016/j.cardiores.2005.07.013. PMID 16154551.

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Tirofiban

ADP receptor/P2Y₁₂ inhibitors	thienopyridines Clopidogrel Prasugrel Ticlopidine nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor

Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal

Thromboxane inhibitors	thromboxane synthase inhibitors Dipyridamole (+Aspirin) Picotamide receptor antagonist Terutroban^†

Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal

Other	Cloricromen Ditazole

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	low molecular weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin oligosaccharides Fondaparinux Idraparinux heparinoid Danaparoid Dermatan sulfate Sulodexide

Direct Xa inhibitors	xabans Apixaban Betrixaban Darexaban Edoxaban Otamixaban Rivaroxaban

Other

Non-medicinal

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

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