Ilepcimide

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Ilepcimide

Systematic (IUPAC) name
(E)-3-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylprop-2-en-1-one
Clinical data
Legal status	?
Identifiers
CAS number	23434-86-8^Y
ATC code	None
PubChem	CID 641115
ChemSpider	556435^N
UNII	5ML58O200F^Y
Chemical data
Formula	C₁₅H₁₇N O₃
Mol. mass	259.300 g/mol
SMILES C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3
InChI InChI=1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+^N Key:BLPUOQGPBJPXRL-FNORWQNLSA-N^N
N (what is this?) (verify)

Ilepcimide, also known as antiepilepserine, is a piperidine anticonvulsant.^[1] It was synthesized by Chinese researchers as an analogue of piperine, the main alkaloid and phytochemical of black pepper (and of other plants in the Piperaceae family), which has been used in the treatment of epilepsy in traditional Chinese medicine and as a nerve tonic in traditional Iranian medicine.^[2]

Ilepcimide has serotonergic activity.^[1]^[3]^[4]

References

↑ 1.0 1.1 C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. p. 1116. ISBN 978-0-412-46630-4. Retrieved 30 November 2012.
↑ Meyer Rosen (23 September 2005). Delivery System Handbook for Personal Care and Cosmetic Products: Technology, Applications and Formulations. William Andrew. p. 159. ISBN 978-0-8155-1682-8. Retrieved 30 November 2012.
↑ Liu, G.Q., Algeria, S., Ceci, A., Gerattini, S., Gobi, M. and Murai, S. (1984) Stimulation of serotonin synthesis in rat brain after antiepilepserine, an antiepileptic piperine derivative. Biochemical Pharmacology 33:3883-3886
↑ Yan, Q.S., Mishra, P.K., Burger, R.L., Bettendorf, A.F., Jobe, P.C. and Dailey J.W. (1992) Evidence that carbamazepine and antiepilepserine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. J. Pharm & Exp Therap. 261(2):652-659

Barbiturates	Barbexaclone Metharbital Methylphenobarbital Pentobarbital Phenobarbital^# Primidone

Benzodiazepines	Clobazam Clonazepam Clorazepate Diazepam^# Flutoprazepam Lorazepam Midazolam Nimetazepam Nitrazepam Temazepam

Other GABA agents

Aromatic allylic alcohols	Stiripentol

Sulfa drugs	Acetazolamide Ethoxzolamide Sultiame Zonisamide

Channel blockers

Primarily sodium

Hydantoins	Ethotoin Fosphenytoin Mephenytoin Phenytoin^#

Carboxamides	Carbamazepine^# Eslicarbazepine acetate Oxcarbazepine Oxitriptyline Rufinamide

Primarily calcium

Succinimides	Ethosuximide^# Mesuximide Phensuximide

Unknown/ungrouped

Channel openers

Potassium	Retigabine

Indirect GABA agents

Carboxylic acids/ Fatty acid derivatives	GABA transaminase inhibitor: Valproic acid^# (Sodium valproate & Valproate semisodium) Valpromide Valnoctamide Valproate pivoxil GABA reuptake inhibitor: Tiagabine

GABA analogs	Gabapentin Pregabalin Progabide Tolgabide Vigabatrin

Unknown/multiple/
unsorted

Carbamates/sulfamates	Carisbamate^† Emylcamate Felbamate JNJ-26990990^§ Meprobamate Topiramate

Pyrrolidines	Brivaracetam Levetiracetam Nefiracetam Seletracetam

Propionates	Beclamide Lacosamide

Aldehydes	Paraldehyde

Bromides	Potassium bromide Sodium bromide

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proc, drug (N1A/2AB/C/3/4/7A/B/C/D)

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