Ilaprazole

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Ilaprazole

Systematic (IUPAC) name
2-[(RS)-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)-1H-benzimidazole
Clinical data
Trade names	Noltec
Legal status	?
Routes	oral
Identifiers
CAS number	172152-36-2
ATC code	None
PubChem	CID 214351
ChemSpider	185839
UNII	776Q6XX45J^Y
Chemical data
Formula	C₁₉H₁₈N₄O₂S
Mol. mass	366.436820 g/mol
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=C(N2)C=C(C=C3)N4C=CC=C4)OC
InChI InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22) Key:HRRXCXABAPSOCP-UHFFFAOYSA-N

Ilaprazole (trade name Noltec) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It is available in strengths of 5, 10, and 20 mg.

Clinical studies show that ilaprazole is at least as potent a PPI as omeprazole when taken in equivalent doses. Studies also showed that ilaprazole significantly prevented the development of reflux oesophagitis.

Ilaprazole is developed by IL-YANG Pharmaceutical (Korea), and is still under clinical trials with US FDA. It has launched in Korea and China for the treament of GU, DU, and GERD/EE.^[1]

References

↑ "Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3)".

Drugs for acid related disorders: Drugs for peptic ulcer and GERD/GORD (A02B)

H₂ antagonists ("-tidine")

Prostaglandins (E)/analogues ("-prost-")

Proton-pump inhibitors ("-prazole")

Other

See also: Helicobacter pylori eradication protocols

M: DIG

anat (t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug (A2A/2B/3/4/5/6/7/14/16), blte

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