IL1F10
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| Interleukin 1 family, member 10 (theta) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | IL1F10; FIL1-theta; IL-1HY2; IL-38; IL1-theta | ||||||||||||
| External IDs | MGI: 2652548 HomoloGene: 17690 GeneCards: IL1F10 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 84639 | 215274 | |||||||||||
| Ensembl | ENSG00000136697 | ENSMUSG00000046845 | |||||||||||
| UniProt | Q8WWZ1 | Q8R459 | |||||||||||
| RefSeq (mRNA) | NM_032556 | NM_153077 | |||||||||||
| RefSeq (protein) | NP_115945 | NP_694717 | |||||||||||
| Location (UCSC) | Chr 2: 113.83 – 113.83 Mb | Chr 2: 24.29 – 24.29 Mb | |||||||||||
| PubMed search | |||||||||||||
Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene.[1][2][3][4]
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.[4]
References
- ↑ Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW (Dec 2001). "Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14". J Interferon Cytokine Res 21 (11): 899–904. doi:10.1089/107999001753289505. PMID 11747621.
- ↑ Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE (May 2002). "Genomic organization of the interleukin-1 locus". Genomics 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
- ↑ Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K (May 2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
- ↑ 4.0 4.1 "Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)".
Further reading
- Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes.". Genomics 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
- Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13.". Genomics 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134.
- Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene.". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
- Smith DE, Renshaw BR, Ketchem RR, et al. (2000). "Four new members expand the interleukin-1 superfamily.". J. Biol. Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
- Kumar S, McDonnell PC, Lehr R, et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family.". J. Biol. Chem. 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718.
- Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.". Genomics 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.
- Barton JL, Herbst R, Bosisio D, et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities.". Eur. J. Immunol. 30 (11): 3299–308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146.
- Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.". Cytokine 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.
- Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member.". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
- Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.". Journal of Immunology 167 (3): 1440–6. PMID 11466363.
- Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes.". Trends Immunol. 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
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