IKZF4
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| IKAROS family zinc finger 4 (Eos) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | IKZF4; EOS; ZNFN1A4 | ||||||||||||
| External IDs | OMIM: 606239 MGI: 1343139 HomoloGene: 69103 GeneCards: IKZF4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64375 | 22781 | |||||||||||
| Ensembl | ENSG00000123411 | ENSMUSG00000002578 | |||||||||||
| UniProt | Q9H2S9 | Q8C208 | |||||||||||
| RefSeq (mRNA) | NM_022465 | NM_011772 | |||||||||||
| RefSeq (protein) | NP_071910 | NP_035902 | |||||||||||
| Location (UCSC) | Chr 12: 56.4 – 56.43 Mb | Chr 10: 128.63 – 128.65 Mb | |||||||||||
| PubMed search | |||||||||||||
Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.[1][2]
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM][2]
Interactions
IKZF4 has been shown to interact with CTBP1[3] and IKZF1.[1][4]
References
- ↑ 1.0 1.1 Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
- ↑ 2.0 2.1 "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".
- ↑ Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. (Germany) 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.
- ↑ Honma, Y; Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. (NETHERLANDS) 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586.
Further reading
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Bao J, Lin H, Ouyang Y et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250–8. doi:10.1038/nn1342. PMID 15494726.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. PMID 12444977.
- Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
- Nagase T, Nakayama M, Nakajima D et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
- Honma Y, Kiyosawa H, Mori T et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. PMID 10218586.
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