Hypertrophy

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Hypertrophy
Classification and external resources

MeSH	D006984

Hypertrophy results from an increase in cell size, while hyperplasia is from an increase in cell number.

Hypertrophy (from Greek ὑπέρ "excess" + τροφή "nourishment") is the increase in the volume of an organ or tissue due to the enlargement of its component cells. It should be distinguished from hyperplasia, in which the cells remain approximately the same size but increase in number. Although hypertrophy and hyperplasia are two distinct processes, they frequently occur together, such as in the case of the hormonally-induced proliferation and enlargement of the cells of the uterus during pregnancy.

Examples of hypertrophy

Muscular hypertrophy

Main article: Muscle hypertrophy

One of the two most common and visible forms of organ hypertrophy occurs in head muscles in response to strength training (known as muscle hypertrophy). Depending on the type of training, the hypertrophy can occur through increased sarcoplasmic volume or increased contractile proteins.

Ventricular hypertrophy

Main article: Ventricular hypertrophy

Ventricular hypertrophy is the increase in size of the ventricles of the heart. Changes can be beneficial or healthy if they occur in response to aerobic or anaerobic exercise, but ventricular hypertrophy is generally associated with pathological changes due to high blood pressure or other disease states.

Hypertrophy of the breasts

Gigantomastia is the extreme growth of the breasts, i.e. 10 pounds (5 kg) per breast and more. In severe cases it is possible for women to have breasts that weigh well in excess of 20 lb (9 kg) each. Gigantomastia can occur as a rare complication of pregnancy, but also with the more frequently juvenile gigantomastia during puberty (virginal breast hypertrophy).

Hypertrophy of the clitoris

Main article: Clitoromegaly

In the most pronounced cases, clitoromegaly is a symptom of intersexuality since the large clitoris resembles an apple (the different grade of genital ambiguity is commonly measured by the Prader classification ranging, in ascending order of masculinisation, from 1: Female external genitalia with clitoromegaly through 5: Pseudo-phallus looking like normal male external genitalia).

External links

University of California Muscle Physiology Home Page: Hypertrophy

v t e Medicine: Pathology

Principles of pathology	Disease Infection Neoplasia Hemodynamics Ischemia Inflammation Wound healing Cell death Necrosis Liquefactive necrosis Coagulative necrosis Caseous necrosis Fat necrosis Apoptosis Pyknosis Karyorrhexis Karyolysis Cellular adaptation Atrophy Hypertrophy Hyperplasia Dysplasia Metaplasia Squamous Glandular Accumulations pigment Hemosiderin Lipochrome/Lipofuscin Melanin Steatosis

Anatomical pathology	Surgical pathology Cytopathology Autopsy Molecular pathology Forensic pathology Dental pathology Gross examination Histopathology Immunohistochemistry Electron microscopy Immunofluorescence Fluorescence in situ hybridization

Clinical pathology	Clinical chemistry Hematopathology Transfusion medicine Medical microbiology Diagnostic immunology Immunopathology Enzyme assay Mass spectrometry Chromatography Flow cytometry Blood bank Microbiological culture Serology

Specific conditions	Myocardial infarction

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