Hydroxysteroid dehydrogenase

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Steroid numbering.

The hydroxysteroid dehydrogenases are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids.

There are four types, classified by the number of the carbon acted upon:

Carbon From To
3 pregnenolone progesterone
3 17-Hydroxypregnenolone 17-Hydroxyprogesterone
3 dehydroepiandrosterone androstenedione
11 cortisol cortisone
17 androstenedione testosterone
20 progesterone 20-alpha-dihydroprogesterone

See also

Additional images

  • Steroidogenesis

External links

Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
  • B
  • enzm
  • 1.1
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    • 15-18
  • 2.1
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      • 2.7.10
      • 11-12
    • 8
  • 3.1
      • 3.1.3.48
    • 2
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      • 3.4.21
      • 22
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    • 5
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  • 4.1
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  • 5.1
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    • 99
  • 6.1-3
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    • 5-6
Metabolism: lipid metabolism – ketones/cholesterol synthesis enzymes/steroid metabolism
Mevalonate pathway
To HMG-CoA
Ketogenesis
To Mevalonic acid
To DMAPP
Geranyl-
To cholesterol
To lanosterol
7-Dehydrocholesterol path
Desmosterol path
To Bile acids
Steroidogenesis
To pregnenolone
To corticosteroids
To sex hormones
To androgens
To estrogens
Other/ungrouped

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END

anat/phys/devp/horm

noco (d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

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