Hydrangenol

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Hydrangenol

IUPAC name 8-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
Identifiers
CAS number	480-47-7^Y
PubChem	119199
ChemSpider	106486^N
ChEBI	CHEBI:5776^N
Jmol-3D images	Image 1
SMILES C1C(OC(=O)C2=C1C=CC=C2O)C3=CC=C(C=C3)O
InChI InChI=1S/C15H12O4/c16-11-6-4-9(5-7-11)13-8-10-2-1-3-12(17)14(10)15(18)19-13/h1-7,13,16-17H,8H2^N Key: DGKDFNDHPXVXHW-UHFFFAOYSA-N^N InChI=1/C15H12O4/c16-11-6-4-9(5-7-11)13-8-10-2-1-3-12(17)14(10)15(18)19-13/h1-7,13,16-17H,8H2 Key: DGKDFNDHPXVXHW-UHFFFAOYAS
Properties
Molecular formula	C₁₅H₁₂O₄
Molar mass	256.25 g/mol
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Hydrangenol is a dihydroisocoumarin. It can be found in Hydrangea macrophylla, as well as its 8-O-glucoside.^[1] (-)-hydrangenol 4'-O-glucoside^[2] and (+)-hydrangenol 4'-O-glucoside^[3]can be found in Hydrangeae Dulcis Folium, the processed leaves of H. macrophylla var. thunbergii.

References

↑ Matsuda, Hisashi; Simoda, Hiroshi; Yamahara, Johji; Yoshikawa, Masayuki (1999). "Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and Thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats". Biological & Pharmaceutical Bulletin 22 (8): 870–872. doi:10.1248/bpb.22.870. PMID 10480329. INIST:1959604.
↑ Yoshikawa, M; Uchida, E; Chatani, N; Kobayashi, H; Naitoh, Y; Okuno, Y; Matsuda, H; Yamahara, J et al. (1992). "Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium". Chemical & pharmaceutical bulletin 40 (12): 3352–4. doi:10.1248/cpb.40.3352. PMID 1363465. |displayauthors= suggested (help)
↑ Yoshikawa, M; Matsuda, H; Shimoda, H; Shimada, H; Harada, E; Naitoh, Y; Miki, A; Yamahara, J et al. (1996). "Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-O-glucoside". Chemical & pharmaceutical bulletin 44 (8): 1440–7. doi:10.1248/cpb.44.1440. PMID 8795265. INIST:3226693. |displayauthors= suggested (help)

v t e Types of isocoumarins

Aglycones	Bergenon Thunberginol A and B

Dihydroisocoumarins	Hydrangenol Mellein 6-Hydroxymellein 6-Methoxymellein Monocerin Phyllodulcin Thunberginol C, D, E and G

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