HolE

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DNA pol III theta subunit
Identifiers
Organism	Escherichia coli (str. K-12 substr. MG1655)
Symbol	holE
Entrez	947471
RefSeq (Prot)	NP_416356.1
UniProt	P0ABS8
Other data
EC number	2.7.7.7
Chromosome	genome: 1.92 - 1.92 Mb

DNA polymerase III, theta subunit

structure of the e. coli pol iii epsilon-hot proofreading complex

Identifiers

Symbol

DNA_pol3_theta

SCOP

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

In E. coli and other bacteria, holE is a gene that encodes the theta subunit of DNA polymerase III.^[1]

References

↑ Studwell-Vaughan PS, O'Donnell M (June 1993). "DNA polymerase III accessory proteins. V. Theta encoded by holE". J. Biol. Chem. 268 (16): 11785–91. PMID 8505306.

DNA replication (comparing Prokaryotic to Eukaryotic)

Initiation

Prokaryotic (initiation)	Pre-replication complex Cdc6 Helicase dnaA dnaB T7 Primase dnaG

Eukaryotic (preparation in G1 phase)	Pre-replication complex Origin recognition complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence Single-strand binding protein SSBP2 SSBP3 SSBP4 RNase H RNASEH1 RNASEH2A Helicase: HFM1 Primase: PRIM1 PRIM2

Both	Origin of replication/Ori/Replicon Replication fork Lagging and leading strands Okazaki fragment Primer

Replication

Prokaryotic (elongation)	DNA polymerase III holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase: DNA polymerase I Klenow fragment

Eukaryotic (synthesis in S phase)	Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase: delta POLD1 POLD2 POLD3 POLD4 DNA clamp PCNA

Both	Movement: Processivity DNA ligase

Termination

Telomere: Telomerase
- TERT
- TERC
- DKC1

See also: DNA replication and repair-deficiency disorder B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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