HolC

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DNA pol III chi subunit
Identifiers
Organism	Escherichia coli (str. K-12 substr. MG1655)
Symbol	holC
Entrez	948787
RefSeq (Prot)	NP_418680.1
UniProt	P28905
Other data
EC number	2.7.7.7
Chromosome	genome: 4.48 - 4.48 Mb

DNA polymerase III chi subunit, HolC

crystal structure of chi and psi subunit heterodimer from dna pol iii

Identifiers

Symbol

DNA_pol3_chi

SCOP

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

In E. coli and other bacteria, holC is a gene that encodes the chi subunit of DNA polymerase III.^[1]

References

↑ Xiao H, Crombie R, Dong Z, Onrust R, O'Donnell M (June 1993). "DNA polymerase III accessory proteins. III. holC and holD encoding chi and psi". J. Biol. Chem. 268 (16): 11773–8. PMID 8389364.

DNA replication (comparing Prokaryotic to Eukaryotic)

Initiation

Prokaryotic (initiation)	Pre-replication complex Cdc6 Helicase dnaA dnaB T7 Primase dnaG

Eukaryotic (preparation in G1 phase)	Pre-replication complex Origin recognition complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence Single-strand binding protein SSBP2 SSBP3 SSBP4 RNase H RNASEH1 RNASEH2A Helicase: HFM1 Primase: PRIM1 PRIM2

Both	Origin of replication/Ori/Replicon Replication fork Lagging and leading strands Okazaki fragment Primer

Replication

Prokaryotic (elongation)	DNA polymerase III holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase: DNA polymerase I Klenow fragment

Eukaryotic (synthesis in S phase)	Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase: delta POLD1 POLD2 POLD3 POLD4 DNA clamp PCNA

Both	Movement: Processivity DNA ligase

Termination

Telomere: Telomerase
- TERT
- TERC
- DKC1

See also: DNA replication and repair-deficiency disorder B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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