HEY1

From Wikipedia, the free encyclopedia
Hairy/enhancer-of-split related with YRPW motif 1

PDB rendering based on 2db7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsHEY1; BHLHb31; CHF2; HERP2; HESR1; HRT-1; OAF1
External IDsOMIM: 602953 MGI: 1341800 HomoloGene: 7756 GeneCards: HEY1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2346215213
EnsemblENSG00000164683ENSMUSG00000040289
UniProtQ9Y5J3Q9QUM5
RefSeq (mRNA)NM_001040708NM_010423
RefSeq (protein)NP_001035798NP_034553
Location (UCSC)Chr 8:
80.68 – 80.68 Mb
Chr 3:
8.66 – 8.67 Mb
PubMed search

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.[1][2][3]

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants.[3]

References

  1. Leimeister C, Externbrink A, Klamt B, Gessler M (Sep 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. 
  2. Kokubo H, Lun Y, Johnson RL (Aug 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochem Biophys Res Commun 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790. 
  3. 3.0 3.1 "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1". 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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