HCN2
From Wikipedia, the free encyclopedia
| Hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | |||||||||||||
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 PDB rendering based on 1q3e. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | HCN2; BCNG-2; BCNG2; HAC-1 | ||||||||||||
| External IDs | OMIM: 602781 MGI: 1298210 HomoloGene: 31022 IUPHAR: HCN2 ChEMBL: 1795172 GeneCards: HCN2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 610 | 15166 | |||||||||||
| Ensembl | ENSG00000099822 | ENSMUSG00000020331 | |||||||||||
| UniProt | Q9UL51 | O88703 | |||||||||||
| RefSeq (mRNA) | NM_001194 | NM_008226 | |||||||||||
| RefSeq (protein) | NP_001185 | NP_032252 | |||||||||||
| Location (UCSC) | Chr 19: 0.59 – 0.62 Mb | Chr 10: 79.72 – 79.74 Mb | |||||||||||
| PubMed search | |||||||||||||
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.[1][2][3][4]
Interactions
HCN2 has been shown to interact with HCN1[5][6] and HCN4.[5]
Function
The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.[7]
See also
References
- ↑ Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc Natl Acad Sci U S A 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
- ↑ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.
- ↑ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
- ↑ "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2".
- ↑ 5.0 5.1 Much, Barbara; Wahl-Schott Christian, Zong Xiangang, Schneider Angela, Baumann Ludwig, Moosmang Sven, Ludwig Andreas, Biel Martin (Oct 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. (United States) 278 (44): 43781–6. doi:10.1074/jbc.M306958200. ISSN 0021-9258. PMID 12928435.
- ↑ Proenza, Catherine; Tran Neil, Angoli Damiano, Zahynacz Kristin, Balcar Petr, Accili Eric A (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". J. Biol. Chem. (United States) 277 (33): 29634–42. doi:10.1074/jbc.M200504200. ISSN 0021-9258. PMID 12034718.
- ↑ "Gene find may lead to pills that kill chronic pain". The Times Of India. 10 September 2011.
Further reading
- Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain.". Hum. Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901.
- Ludwig A, Zong X, Stieber J, et al. (1999). "Two pacemaker channels from human heart with profoundly different activation kinetics.". EMBO J. 18 (9): 2323–9. doi:10.1093/emboj/18.9.2323. PMC 1171315. PMID 10228147.
- Vaccari T, Moroni A, Rocchi M, et al. (1999). "The human gene coding for HCN2, a pacemaker channel of the heart.". Biochim. Biophys. Acta 1446 (3): 419–25. PMID 10524219.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Ulens C, Tytgat J (2001). "Functional heteromerization of HCN1 and HCN2 pacemaker channels.". J. Biol. Chem. 276 (9): 6069–72. doi:10.1074/jbc.C000738200. PMID 11133998.
- Proenza C, Tran N, Angoli D, et al. (2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.". J. Biol. Chem. 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718.
- Qu J, Altomare C, Bucchi A, et al. (2003). "Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.". Pflugers Arch. 444 (5): 597–601. doi:10.1007/s00424-002-0860-7. PMID 12194012.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sesti F, Rajan S, Gonzalez-Colaso R, et al. (2003). "Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel.". Nat. Neurosci. 6 (4): 353–61. doi:10.1038/nn1028. PMID 12640457.
- Stieber J, Thomer A, Much B, et al. (2003). "Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.". J. Biol. Chem. 278 (36): 33672–80. doi:10.1074/jbc.M305318200. PMID 12813043.
- Bender RA, Soleymani SV, Brewster AL, et al. (2003). "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.". J. Neurosci. 23 (17): 6826–36. PMID 12890777.
- Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Michels G, Er F, Khan I, et al. (2005). "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.". Circulation 111 (4): 399–404. doi:10.1161/01.CIR.0000153799.65783.3A. PMID 15687126.
- Akhavan A, Atanasiu R, Noguchi T, et al. (2005). "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization.". J. Cell. Sci. 118 (Pt 13): 2803–12. doi:10.1242/jcs.02423. PMID 15961404.
- Calloe K, Elmedyb P, Olesen SP, et al. (2006). "Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.". Biophys. J. 89 (3): 2159–69. doi:10.1529/biophysj.105.063792. PMC 1366717. PMID 15980171.
External links
- HCN2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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