Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase

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glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
Identifiers
EC number 2.4.1.122
CAS number 97089-61-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (EC 2.4.1.122) is an enzyme that catalyzes the chemical reaction

UDP-galactose + glycoprotein N-acetyl-D-galactosamine \rightleftharpoons UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine

Thus, the two substrates of this enzyme are UDP-galactose and glycoprotein N-acetyl-D-galactosamine, whereas its two products are UDP and glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase. This enzyme is also called uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1.

See also

References

    • Hesford FJ, Berger EG, Van den Eijnden DH (1981). "Identification of the product formed by human erythrocyte galactosyltransferase". Biochim. Biophys. Acta. 659 (2): 302–11. PMID 6789880. 
    • Mendicino J, Sivakami S, Davila M, Chandrasekaran EV (1982). "Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa". J. Biol. Chem. 257 (7): 3987–94. PMID 6801057. 
    • Schachter H, Narasimhan S, Gleeson P, Vella G (1983). "Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type". Methods Enzymol. 98: 98–134. doi:10.1016/0076-6879(83)98143-0. PMID 6366476. 
    2.4.1: Hexosyl-
    transferases
    Glucosyl-
    Galactosyl-
    Glucuronosyl-
    Fucosyl-
    Mannosyl-
    2.4.2: Pentosyl-
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    Ribose
    ADP-ribosyltransferase
    Phosphoribosyltransferase
    Other
    Other
    2.4.99: Sialyl
    transferases
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