Globoidnan A
Globoidnan A | |
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IUPAC name (2R)-(3,4-dihydroxyphenyl)-2-{[4-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2-naphthoyl]oxy}propanoic acid | |
Identifiers | |
CAS number | 827322-48-5 |
PubChem | 3013628 |
ChemSpider | 26333277 |
Jmol-3D images | {{#if:c1cc(c(cc1C[C@H](C(=O)O)OC(=O)c2cc3cc(c(cc3c(c2)c4ccc(c(c4)O)O)O)O)O)O|Image 1 |
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Properties | |
Molecular formula | C26H20O10 |
Molar mass | 492.43 g mol−1 |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
Infobox references | |
Globoidnan A is a lignan found in Eucalyptus globoidea, a tree native to Australia.
The molecule has been found to inhibit the action of HIV integrase,[1] an enzyme which is responsible for the introduction of HIV viral DNA into a host's cellular DNA. It is not known that globoidnan A inhibits the action of other retroviral integrases.
References
- ↑ Ovenden SP, Yu J, Wan SS, et al. (2004). "Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase". Phytochemistry 65 (24): 3255–59. doi:10.1016/j.phytochem.2004.10.006. PMID 15561191.
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