Gem-associated protein 7
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| Gem (nuclear organelle) associated protein 7 | |||||||||||||
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 PDB rendering based on 1y96. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GEMIN7; SIP3 | ||||||||||||
| External IDs | OMIM: 607419 MGI: 1916981 HomoloGene: 11668 GeneCards: GEMIN7 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Species | Human | Mouse | |||||||||||
| Entrez | 79760 | 69731 | |||||||||||
| Ensembl | ENSG00000142252 | ENSMUSG00000044709 | |||||||||||
| UniProt | Q9H840 | Q9CWY4 | |||||||||||
| RefSeq (mRNA) | NM_001007269 | NM_027189 | |||||||||||
| RefSeq (protein) | NP_001007270 | NP_081465 | |||||||||||
| Location (UCSC) | Chr 19: 45.58 – 45.59 Mb | Chr 7: 19.56 – 19.57 Mb | |||||||||||
| PubMed search | |||||||||||||
Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[1][2]
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[2]
Interactions
Gem-associated protein 7 has been shown to interact with SMN1[1][3] and Gem-associated protein 6.[1][4]
References
- ↑ 1.0 1.1 1.2 Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J Biol Chem 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
- ↑ 2.0 2.1 "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7".
- ↑ Pellizzoni, Livio; Baccon Jennifer, Rappsilber Juri, Mann Matthias, Dreyfuss Gideon (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. (United States) 277 (9): 7540–5. doi:10.1074/jbc.M110141200. ISSN 0021-9258. PMID 11748230.
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2007). "Gemin8 is required for the architecture and function of the survival motor neuron complex". J. Biol. Chem. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Grimmler M, Otter S, Peter C, et al. (2006). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Hum. Mol. Genet. 14 (20): 3099–111. doi:10.1093/hmg/ddi343. PMID 16159890.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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