Gadobutrol

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Gadobutrol
Systematic (IUPAC) name
gadolinium(III) 2,2',2''-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
Clinical data
AHFS/Drugs.com International Drug Names
Licence data US FDA:link
Pregnancy cat. C (US)
Legal status POM (UK) ℞-only (US)
Routes IV
Identifiers
CAS number 138071-82-6 YesY
ATC code V08CA09
PubChem CID 72057
DrugBank DB06703
UNII 1BJ477IO2L YesY
KEGG D07420 YesY
ChEBI CHEBI:68841 N
ChEMBL CHEMBL1628503 N
Chemical data
Formula C18H31GdN4O9 
Mol. mass 604.710 g/mol
 N (what is this?)  (verify)

Gadobutrol (INN) (Gd-DO3A-butrol) is a gadolinium-based MRI contrast agent (GBCA).

It received marketing approval in Canada[1] and in the United States.[2][3][4]

As of 2007, it was the only GBCA approved at 1.0 molar concentrations.[5]

Gadobutrol is marketed by Bayer Schering Pharma as Gadovist, and by Bayer HealthCare Pharmaceuticals as Gadavist.[6]

References

  1. ↑ Cheng, KT (2007). "Gadobutrol". Molecular Imaging and Contrast Agent Database (MICAD) (Bethesda, MD: National Center for Biotechnology Information (NCBI)). PMID 20641787. NBK23589. 
  2. ↑ http://bayerimaging.com/products/gadavist/index.php
  3. ↑ "FDA approves imaging agent for central nervous system scans" (Press release). U.S. Food and Drug Administration (FDA). March 15, 2011. Retrieved March 31, 2011. 
  4. ↑ "U.S. FDA Approves Bayer’s Gadavist (Gadobutrol) Injection for MRI of the Central Nervous System" (Press release). Bayer HealthCare Pharmaceuticals. March 14, 2011. Retrieved March 31, 2011. 
  5. ↑ "Gadobutrol 1.0-molar in Cardiac Magnetic Resonance Imaging (MRI) - Further Enhancing the Capabilities of Contrast-enhanced MRI in Ischaemic and Non-ischaemic Heart Disease?"
  6. ↑ "Gadavist full prescribing information". Retrieved 2011-03-14. 
X-ray and CT
Iodinated,
Water soluble
Nephrotropic,
high osmolar
Nephrotropic,
low osmolar
Hepatotropic
Iodinated,
Water insoluble
Non-iodinated
MRI
Paramagnetic
Other
Ultrasound
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